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  1. No Access

    Article

    Investigating the candidacy of the serotype specific rhamnan polysaccharide based glycoconjugates to prevent disease caused by the dental pathogen Streptococcus mutans

    Dental caries remains a major health issue and the Gram-positive bacterium Streptococcus mutans is considered as the major pathogen causing caries. More recently, S. mutans has been recognised as a cause of endoc...

    Frank St. Michael, Qingling Yang, Chantelle Cairns… in Glycoconjugate Journal (2018)

  2. Article

    Open Access

    Targeting surface-layer proteins with single-domain antibodies: a potential therapeutic approach against Clostridium difficile-associated disease

    Clostridium difficile is a leading cause of death from gastrointestinal infections in North America. Antibiotic therapy is effective, but the high incidence of relapse and the rise in hyp...

    Hiba Kandalaft, Greg Hussack, Annie Aubry… in Applied Microbiology and Biotechnology (2015)

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    Article

    Investigating the candidacy of a lipoteichoic acid-based glycoconjugate as a vaccine to combat Clostridium difficile infection

    A lipoteichoic acid has recently been shown to be conserved in the majority of strains from Clostridium difficile and as such is being considered as a possible vaccine antigen. In this study we examine the candid...

    Andrew D. Cox, Frank St. Michael, Annie Aubry… in Glycoconjugate Journal (2013)