3 Result(s)
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Article
Open AccessSignatures of copy number alterations in human cancer
Gains and losses of DNA are prevalent in cancer and emerge as a consequence of inter-related processes of replication stress, mitotic errors, spindle multipolarity and breakage–fusion–bridge cycles, among othe...
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Article
Open AccessRecurrent rearrangements of FOS and FOSB define osteoblastoma
The transcription factor FOS has long been implicated in the pathogenesis of bone tumours, following the discovery that the viral homologue, v-fos, caused osteosarcoma in laboratory mice. However, mutations of FO...
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Article
Open AccessDecoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state
Transcriptional reprogramming of proliferative melanoma cells into a phenotypically distinct invasive cell subpopulation is a critical event at the origin of metastatic spreading. Here we generate transcriptom...
