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    Article

    Glutamatergic synapse in autism: a complex story for a complex disorder

    Autism spectrum disorder (ASD) is a neurodevelopmental disorder whose pathophysiological mechanisms are still unclear. Hypotheses suggest a role for glutamate dysfunctions in ASD development, but clinical stud...

    Laurent Galineau, Nicolas Arlicot, Anne-Claire Dupont in Molecular Psychiatry (2023)

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    Open Access

    Study of influence of the glutamatergic concentration of [18F]FPEB binding to metabotropic glutamate receptor subtype 5 with N-acetylcysteine challenge in rats and SRM/PET study in human healthy volunteers

    Altered glutamate signaling is thought to be involved in a myriad of psychiatric disorders. Positron emission tomography (PET) imaging with [18F]FPEB allows assessing dynamic changes in metabotropic glutamate rec...

    Anne-Claire Dupont, Sophie Serrière, Laurent Barantin in Translational Psychiatry (2021)

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    Open Access

    Fully automated radiosynthesis of [18F]LBT999 on TRACERlab FXFN and AllinOne modules, a PET radiopharmaceutical for imaging the dopamine transporter in human brain

    Fluorine labelled 8-((E)-4-fluoro-but-2-enyl)-3β-p-tolyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid methyl ester ([18F]LBT999) is a selective radioligand for the in vivo neuroimaging and quantification of the ...

    Christine Vala, Céline Mothes, Gabrielle Chicheri in EJNMMI Radiopharmacy and Chemistry (2020)

  4. Article

    Open Access

    [18F]FDDNP performed better than [18F] Florbetapir to distinguish transthyretin cardiac amyloidosis (TTR-CA) patients from healthy controls: an ex vivo study

    Anne-Claire Dupont, Denis Guilloteau, Rana Ben-Azzouna in Orphanet Journal of Rare Diseases (2015)