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Article
Open AccessDevelopment and prospective validation of an artificial intelligence-based smartphone app for rapid intraoperative pituitary adenoma identification
Intraoperative pathology consultation plays a crucial role in tumor surgery. The ability to accurately and rapidly distinguish tumor from normal tissue can greatly impact intraoperative surgical oncology manag...
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Article
Open AccessA genome-wide association study of contralateral breast cancer in the Women’s Environmental Cancer and Radiation Epidemiology Study
Contralateral breast cancer (CBC) is the most common second primary cancer diagnosed in breast cancer survivors, yet the understanding of the genetic susceptibility of CBC, particularly with respect to common ...
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Article
Open AccessCDKN2A/B mutations and allele-specific alterations stratify survival outcomes in IDH-mutant astrocytomas
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Article
Open AccessIncidence of HER2-expressing brain metastases in patients with HER2-null breast cancer: a matched case analysis
The HER2-directed antibody-drug conjugate trastuzumab deruxtecan is active against lower levels of HER2 expression than prior-generation therapies. The rate of HER2 expression in brain metastases among patient...
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Article
Correction to: Salvage resection plus cesium-131 brachytherapy durably controls post-SRS recurrent brain metastases
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Salvage resection plus cesium-131 brachytherapy durably controls post-SRS recurrent brain metastases
Salvage of recurrent previously irradiated brain metastases (rBrM) is a significant challenge. Resection without adjuvant re-irradiation is associated with a high local failure rate, while reirradiation only p...
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Article
Open AccessRosai–Dorfman–Destombes disease of the nervous system: a systematic literature review
Rosai–Dorfman–Destombes disease (RDD) is a rare histiocytic disorder with heterogeneous clinical manifestations and rare neurologic involvement. The existing clinical literature about neurologic RDD has yet to...
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Quantitative assessment of circulating tumor cells in cerebrospinal fluid as a clinical tool to predict survival in leptomeningeal metastases
Circulating tumor cells in cerebrospinal fluid are a quantitative diagnostic tool for leptomeningeal metastases from solid tumors, but their prognostic significance is unclear. Our objective was to evaluate CS...
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Salvage resection of recurrent previously irradiated brain metastases: tumor control and radiation necrosis dependency on adjuvant re-irradiation
The efficacy of salvage resection (SR) of recurrent brain metastases (rBrM) following stereotactic radiosurgery (SRS) is undefined. We sought to describe local recurrence (LR) and radiation necrosis (RN) rates...
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Open AccessMammographic texture features associated with contralateral breast cancer in the WECARE Study
To evaluate whether mammographic texture features were associated with second primary contralateral breast cancer (CBC) risk, we created a “texture risk score” using pre-treatment mammograms in a case–control ...
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Article
Cerebrospinal fluid diversion for leptomeningeal metastasis: palliative, procedural and oncologic outcomes
Leptomeningeal metastasis (LM) occurs in 3–5% of patients with solid metastatic tumors and often portends a severe prognosis including symptomatic hydrocephalus and intracranial hypertension. Cerebrospinal flu...
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The effect of surgery on radiation necrosis in irradiated brain metastases: extent of resection and long-term clinical and radiographic outcomes
Radiation therapy is a cornerstone of brain metastasis (BrM) management but carries the risk of radiation necrosis (RN), which can require resection for palliation or diagnosis. We sought to determine the rela...
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Article
Open Access18F-FDG PET/CT versus anatomic imaging for evaluating disease extent and clinical trial eligibility in Erdheim-Chester disease: results from 50 patients in a registry study
The aim of this study was to [1] characterize distribution of Erdheim-Chester Disease (ECD) by 18F-FDG PET/CT and [2] determine the utility of metabolic (18F-FDG PET/CT) imaging versus anatomic imaging (CT or MRI...
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Article
Characterization of MGMT and EGFR protein expression in glioblastoma and association with survival
Understanding the molecular landscape of glioblastoma (GBM) is increasingly important in the age of targeted therapy. O-6-Methylguanine-DNA methyltransferase (MGMT) promoter methylation and EGFR amplification are...
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Article
Longitudinal cognitive assessment in patients with primary CNS lymphoma treated with induction chemotherapy followed by reduced-dose whole-brain radiotherapy or autologous stem cell transplantation
The standard treatment for primary central nervous system lymphoma (PCNSL) involves induction methotrexate-based chemotherapy with or without consolidation whole brain radiotherapy (WBRT). As WBRT carries a su...
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Article
Tracking tumour evolution in glioma through liquid biopsies of cerebrospinal fluid
Diffuse gliomas are the most common malignant brain tumours in adults and include glioblastomas and World Health Organization (WHO) grade II and grade III tumours (sometimes referred to as lower-grade gliomas)...
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Open AccessCYP2D6 phenotype, tamoxifen, and risk of contralateral breast cancer in the WECARE Study
Tamoxifen treatment greatly reduces a woman’s risk of develo** a second primary breast cancer. There is, however, substantial variability in treatment response, some of which may be attributed to germline ge...
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Open AccessThe association of mammographic density with risk of contralateral breast cancer and change in density with treatment in the WECARE study
Mammographic density (MD) is an established predictor of risk of a first breast cancer, but the relationship of MD to contralateral breast cancer (CBC) risk is not clear, including the roles of age, mammogram ...
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Article
Increased risk of arterial thromboembolism in older men with breast cancer
Male breast cancer is a rare and understudied disease predominantly affecting men over age 60. Risk of arterial thromboembolic events (ATE) in men increases with age. We examined ATE risk following primary bre...
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Open AccessHormone receptor status of a first primary breast cancer predicts contralateral breast cancer risk in the WECARE study population
Previous population-based studies have described first primary breast cancer tumor characteristics and their association with contralateral breast cancer (CBC) risk. However, information on influential covaria...
