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Article
Open AccessTreatment outcome according to genetic tumour alterations and clinical characteristics in digestive high-grade neuroendocrine neoplasms
Chemotherapy has limited efficacy in advanced digestive high-grade neuroendocrine neoplasms (HG-NEN) and prognosis is dismal. Predictive markers for palliative chemotherapy are lacking, and prognostic markers ...
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Article
Open AccessRole of the fatty pancreatic infiltration in pancreatic oncogenesis
Although pancreatic precancerous lesions are known to be related to obesity and fatty pancreatic infiltration, the mechanisms remain unclear. We assessed the role of fatty infiltration in the process of pancre...
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Article
Open AccessPhase II study of everolimus and temozolomide as first-line treatment in metastatic high-grade gastroenteropancreatic neuroendocrine neoplasms
The optimal treatment for metastatic high-grade gastroenteropancreatic (GEP) neuroendocrine neoplasms when Ki-67 ≤55% is unknown. A prospective multi-centre phase 2 study was performed to evaluate the efficacy...
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Article
An update on the development of concepts, diagnostic criteria, and challenging issues for neuroendocrine neoplasms across different digestive organs
Digestive neuroendocrine neoplasms (NENs) are a group of heterogeneous neoplasms found throughout the digestive tract, with different behaviour and genetic background. In the last few years, nomenclature and W...
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Reference Work Entry In depth
Glucagon Cell Hyperplasia and Neoplasia
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Reference Work Entry In depth
Glucagonoma
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Article
Pathogenic ATM Variant-Harbouring Well-Differentiated Aggressive Type 1 Gastric Neuroendocrine Tumour with High-grade Features (G3 NET): a New Addition to the Clinical and Pathological Spectrum of Gastric Neuroendocrine Neoplasms
Gastric type 1 neuroendocrine tumours are considered to have low rates of proliferation and a good prognosis. We report here a patient with an aggressive well-differentiated high-grade gastric neuroendocrine t...
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Article
Serotonin immunoreactive pancreatic neuroendocrine neoplasm associated with main pancreatic duct dilation: a recognizable entity with excellent long-term outcome
Dilatation of the main pancreatic duct (MPD) is rare in pancreatic neuroendocrine neoplasm (panNEN) and may be due to different mechanisms. We compared the imaging and pathological characteristics as well as t...
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Article
Open AccessBariatric surgery induces a new gastric mucosa phenotype with increased functional glucagon-like peptide-1 expressing cells
Glucagon-Like Peptide-1 (GLP-1) undergoes rapid inactivation by dipeptidyl peptidase-4 (DPP4) suggesting that target receptors may be activated by locally produced GLP-1. Here we describe GLP-1 positive cells ...
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Article
Correction to: Prediction of pancreatic neuroendocrine tumour grade with MR imaging features: added value of diffusion-weighted imaging
The original version of this article, published on 19 August 2016, unfortunately contained a mistake.
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Article
Clinicopathological and Molecular Study of Peritoneal Carcinomatosis Associated with Non-Small Cell Lung Carcinoma
To retrospectively characterize the molecular features of Non-Small Cell Lung Carcinomas (NSCLC) with peritoneal carcinomatosis (PC), clinicopathological data of 12 patients diagnosed with NSCLC and PC between...
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Article
Open AccessLong-term consequences of one anastomosis gastric bypass on esogastric mucosa in a preclinical rat model
Although bariatric surgery is proven to sustain weight loss in morbidly obese patients, long-term adverse effects have yet to be fully characterized. This study compared the long-term consequences of two commo...
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Living Reference Work Entry In depth
Glucagon Cell Hyperplasia and Neoplasia
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Living Reference Work Entry In depth
Glucagonoma
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Article
Non-branched microcysts of the pancreas on MR imaging of patients with pancreatic tumors who had pancreatectomy may predict the presence of pancreatic intraepithelial neoplasia (PanIN): a preliminary study
To evaluate whether pancreatic parenchymal abnormalities on magnetic resonance imaging (MRI) are associated with pancreatic intraepithelial neoplasia (PanIN) on histology.
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Article
Open AccessObesity-induced pancreatopathy in rats is reversible after bariatric surgery
Obesity is a risk factor for pancreatic diseases. Bariatric surgery is one of the most efficient treatments of morbid obesity. The aims were to assess pancreatic endocrine and exocrine lesions in obese rats, t...
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Article
A gastric MANEC with an adenocarcinoma of fundic-gland type as exocrine component
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Article
Long-Term Evaluation of Biliary Reflux After Experimental One-Anastomosis Gastric Bypass in Rats
Controversy remains regarding biliary reflux after one-anastomosis gastric bypass (OAGB). The aim of this “pilot” study was to analyze biliary reflux and its potential long-term consequences on esogastric muco...
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Article
Prediction of pancreatic neuroendocrine tumour grade with MR imaging features: added value of diffusion-weighted imaging
To evaluate the value of MR imaging including diffusion-weighted imaging (DWI) for the grading of pancreatic neuroendocrine tumours (pNET).
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Chapter
Glucagonoma
Glucagonoma represents about 2 % of the pancreatic neuroendocrine tumors (PanNET). They are accompanied by a diabetico-dermatogenic functional syndrome with typical clinical symptoms due to the raised hormone....
