14 Result(s)
-
Article
Open AccessMedication use during pregnancy and the risk of gastroschisis: a systematic review and meta-analysis of observational studies
The aetiology of gastroschisis is considered multifactorial. We conducted a systematic review and meta-analysis to assess whether the use of medications during pregnancy, is associated with the risk of gastros...
-
Article
Open AccessPrescriptions for insulin and insulin analogues in children with and without major congenital anomalies: a data linkage cohort study across six European regions
Are children with major congenital anomalies more likely to develop diabetes requiring insulin therapy, as indicated by prescriptions for insulin, than children without congenital anomalies? The aim of this st...
-
Article
Open AccessAccuracy of congenital anomaly coding in live birth children recorded in European health care databases, a EUROlinkCAT study
Electronic health care databases are increasingly being used to investigate the epidemiology of congenital anomalies (CAs) although there are concerns about their accuracy. The EUROlinkCAT project linked data ...
-
Article
Open AccessInformation needs of parents of children with congenital anomalies across Europe: a EUROlinkCAT survey
Parents of children who have a congenital anomaly can experience significant worry about their child’s health. Access to clear, helpful, and trustworthy information can provide a valuable source of support. In...
-
Article
Open AccessSurvival of children with rare structural congenital anomalies: a multi-registry cohort study
Congenital anomalies are the leading cause of perinatal, neonatal and infant mortality in developed countries. Large long-term follow-up studies investigating survival beyond the first year of life in children...
-
Article
Signal Detection in EUROmediCAT: Identification and Evaluation of Medication–Congenital Anomaly Associations and Use of VigiBase as a Complementary Source of Reference
Knowledge on the safety of medication use during pregnancy is often sparse. Pregnant women are generally excluded from clinical trials, and there is a dependence on post-marketing surveillance to identify tera...
-
Article
Open AccessSurvival of patients with rare diseases: a population-based study in Tuscany (Italy)
Rare diseases (RDs) encompass a heterogeneous group of life-threatening or chronically debilitating conditions that individually affect a small number of subjects but overall represent a major public health is...
-
Article
Open AccessEpidemiology of systemic sclerosis: a multi-database population-based study in Tuscany (Italy)
Systemic Sclerosis (SSc) is a chronic autoimmune disease with a complex pathogenesis that includes vascular injury, abnormal immune activation, and tissue fibrosis. We provided a complete epidemiological chara...
-
Article
Spectrum of congenital anomalies among VACTERL cases: a EUROCAT population-based study
The VACTERL (Vertebral anomalies, Anal atresia, Cardiac malformations, Tracheo-Esophageal fistula, Renal anomalies, Limb abnormalities) association is the non-random occurrence of at least three of these conge...
-
Article
Open AccessBeta-Blocker Use in Pregnancy and Risk of Specific Congenital Anomalies: A European Case-Malformed Control Study
The prevalence of chronic hypertension is increasing in pregnant women. Beta-blockers are among the most prevalent anti-hypertensive agents used in early pregnancy.
-
Article
Open AccessEpidemiology of hypospadias in Europe: a registry-based study
Hypospadias is a common congenital malformation. The prevalence of hypospadias has a large geographical variation, and recent studies have reported both increasing and decreasing temporal trends. It is unclear...
-
Article
Open AccessImproving Information on Maternal Medication Use by Linking Prescription Data to Congenital Anomaly Registers: A EUROmediCAT Study
Research on associations between medication use during pregnancy and congenital anomalies is significative for assessing the safe use of a medicine in pregnancy. Congenital anomaly (CA) registries do not have ...
-
Article
Selective serotonin reuptake inhibitor antidepressant use in first trimester pregnancy and risk of specific congenital anomalies: a European register-based study
Evidence of an association between early pregnancy exposure to selective serotonin reuptake inhibitors (SSRI) and congenital heart defects (CHD) has contributed to recommendations to weigh benefits and risks c...
-
Article
Open AccessHolt Oram syndrome: a registry-based study in Europe
Holt-Oram syndrome (HOS) is an autosomal dominant disorder characterised by upper limb anomalies and congenital heart defects. We present epidemiological and clinical aspects of HOS patients using data from EU...
