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Article

In search of a small molecule agonist of the relaxin receptor RXFP1 for the treatment of liver fibrosis

The peptide hormone human relaxin-2 (H2-RLX) has emerged as a potential therapy for cardiovascular and fibrotic diseases, but its short in vivo half-life is an obstacle to long-term administration. The discovery ...

Andrew McBride, Anna M. Hoy, Mark J. Bamford, Danuta E. Mossakowska… in Scientific Reports (2017)