10 Result(s)
within
Anna M. Blom
Rheumatology
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Article
Open AccessPlasma C4d as marker for lupus nephritis in systemic lupus erythematosus
In the present study, we sought to evaluate the complement activation product C4d as a marker for lupus nephritis in systemic lupus erythematosus (SLE).
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Article
The complement system as a potential therapeutic target in rheumatic disease
The complement system provides essential protection against infections but also contributes to the severity of autoimmune diseases
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Article
Open AccessAnalysis of complement biomarkers in systemic sclerosis indicates a distinct pattern in scleroderma renal crisis
The complement system has been implicated in pathogenesis of systemic sclerosis (SSc). The goal of the present study was to evaluate improved complement biomarkers in SSc.
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Open AccessThe complement system is activated in synovial fluid from subjects with knee injury and from patients with osteoarthritis
The complement system is suggested to be involved in the pathogenesis of osteoarthritis (OA), and proinflammatory cytokines may play a role in OA development by inducing proteases. The association between comp...
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Open AccessA subset of patients with systemic lupus erythematosus fails to degrade DNA from multiple clinically relevant sources
Patients with systemic lupus erythematosus (SLE) have a decreased ability to clear cell remnants and multiple deficiencies in the ability to degrade cellular chromatin have been linked to the disease. Since th...
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Article
Open AccessCartilage oligomeric matrix protein-induced complement activation in systemic sclerosis
Complexes between cartilage oligomeric matrix protein (COMP) and the complement activation product C3b have been found in the circulation of patients with rheumatoid arthritis and systemic lupus erythematosus....
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Open AccessDegradation of neutrophil extracellular traps co-varies with disease activity in patients with systemic lupus erythematosus
The ability to degrade neutrophil extracellular traps (NETs) is reduced in a subset of patients with systemic lupus erythematosus (SLE). NETs consist of chromatin covered with antimicrobial enzymes and are nor...
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Article
Open AccessFactor H autoantibodies and deletion of Complement Factor H-Related protein-1 in rheumatic diseases in comparison to atypical hemolytic uremic syndrome
Complement activation is involved in rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and atypical hemolytic uremic syndrome (aHUS). Autoantibodies to complement inhibitor factor H (FH), particula...
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Open AccessSerum COMP-C3b complexes in rheumatic diseases and relation to anti-TNF-α treatment
Cartilage oligomeric matrix protein (COMP) is found at elevated concentrations in sera of patients with joint diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). We recently showed that COMP ac...
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Article
Open AccessMutations in genes encoding complement inhibitors CD46 and CFHaffect the age at nephritis onset in patients with systemic lupus erythematosus
Inherited deficiencies of several complement components strongly predispose to systemic lupus erythematosus (SLE) while deficiencies of complement inhibitors are found in kidney diseases such as atypical hemol...
