6 Result(s)
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Article
Open AccessGenetic structure in the Sherpa and neighboring Nepalese populations
We set out to describe the fine-scale population structure across the Eastern region of Nepal. To date there is relatively little known about the genetic structure of the Sherpa residing in Nepal and their gen...
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Article
Adaptation – not by sweeps alone
There has been recent progress in identifying selective sweeps underlying a range of adaptations. Jonathan Pritchard and Anna Di Rienzo argue that many adaptive events in natural populations may occur by polyg...
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Article
Spatial patterns of variation due to natural selection in humans
Marked geographic patterns for the distribution of some heritable traits are observed in humans, including traits related to disease risk, pathogen resistance ...
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Article
Open AccessPrevalence of common disease-associated variants in Asian Indians
Asian Indians display a high prevalence of diseases linked to changes in diet and environment that have arisen as their lifestyle has become more westernized. Using 1200 genome-wide polymorphisms in 432 indivi...
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Article
Toward a more accurate time scale for the human mitochondrial DNA tree
Several estimates of the time of occurrence of the most recent common mitochondrial DNA (mtDNA) ancestor of modern humans have been made. Estimates derived from noncoding regions based on a model that classifi...
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Article
Genome map** by arbitrary amplification of yeast artificial chromosomes
Several methods have been described for using the polymerase chain reaction (PCR) to isolate fragments of DNA for genome map**. We have developed an approach for isolating discrete fragments by amplifying DN...
