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Article
BigNeuron: a resource to benchmark and predict performance of algorithms for automated tracing of neurons in light microscopy datasets
BigNeuron is an open community bench-testing platform with the goal of setting open standards for accurate and fast automatic neuron tracing. We gathered a diverse set of image volumes across several species t...
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Article
Open AccessThe new X-ray/visible microscopy MAXWELL technique for fast three-dimensional nanoimaging with isotropic resolution
Microscopy by Achromatic X-rays With Emission of Laminar Light (MAXWELL) is a new X-ray/visible technique with attractive characteristics including isotropic resolution in all directions, large-volume imaging ...
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Article
Diverse Community Structures in the Neuronal-Level Connectome of the Drosophila Brain
Drosophila melanogaster is one of the most important model animals in neurobiology owing to its manageable brain size, complex behaviour, and extensive genetic tools. However, without a comprehensive map of the b...
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Article
Delivery of nitric oxide with a nanocarrier promotes tumour vessel normalization and potentiates anti-cancer therapies
Abnormal tumour vasculature has a significant impact on tumour progression and response to therapy. Nitric oxide (NO) regulates angiogenesis and maintains vascular homeostasis and, thus, can be delivered to no...
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Article
Open AccessRapid single-wavelength lightsheet localization microscopy for clarified tissue
Optical super-resolution microscopy allows nanoscale imaging of protein molecules in intact biological tissues. However, it is still challenging to perform large volume super-resolution imaging for entire anim...
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Article
Open AccessAsymmetric ephaptic inhibition between compartmentalized olfactory receptor neurons
In the Drosophila antenna, different subtypes of olfactory receptor neurons (ORNs) housed in the same sensory hair (sensillum) can inhibit each other non-synaptically. However, the mechanisms underlying this unde...
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Chapter and Conference Paper
Computing Image Intersection and Union Regions for Drosophila Neurons Based on Multi-core CPUs
With more and more Drosophila Driver and Neuron images, it is an important work to find the similarity relationships among them as the functional inference. There is a general problem that how to find a Drosop...
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Chapter
Multiscale and Multimodal Imaging for Connectomics
Recent advances in optical imaging tools for map** the structural and functional connectomes have greatly augmented our understanding of the brains. The brain is a multilayered and multicompartmental organ w...
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Article
Open AccessUntangling the Tauopathy for Alzheimer’s disease and parkinsonism
Tau is a microtubule-associated protein that mainly localizes to the axon to stabilize axonal microtubule structure and neuronal connectivity. Tau pathology is one of the most common proteinopathies that assoc...
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Article
Kaleido: Visualizing Big Brain Data with Automatic Color Assignment for Single-Neuron Images
Effective 3D visualization is essential for connectomics analysis, where the number of neural images easily reaches over tens of thousands. A formidable challenge is to simultaneously visualize a large number ...
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Article
Soma Detection in 3D Images of Neurons using Machine Learning Technique
Computing and analyzing the neuronal structure is essential to studying connectome. Two important tasks for such analysis are finding the soma and constructing the neuronal structure. Finding the soma is consi...
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Article
Open AccessQ&A: Why use synchrotron x-ray tomography for multi-scale connectome map**?
To understand how information flows and is used in the human brain, we must map neural structures at all levels, providing visualizations similar to those of Google Earth for continents, countries, cities, and...
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Article
Open Access26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3
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Article
Open AccessLong-term memory requires sequential protein synthesis in three subsets of mushroom body output neurons in Drosophila
Creating long-term memory (LTM) requires new protein synthesis to stabilize learning-induced synaptic changes in the brain. In the fruit fly, Drosophila melanogaster, aversive olfactory learning forms several pha...
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Protocol
Optogenetic Manipulation of Selective Neural Activity in Free-Moving Drosophila Adults
Activating selected neurons elicits specific behaviors in Drosophila adults. By combining optogenetics and laser-tracking techniques, we have recently developed an automated laser-tracking and optogenetic manipul...
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Article
Open AccessLarge-scale quantitative analysis of neurons via morphological structures by Fast Automatically Structural Tracing Algorithm (FAST)
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Article
Open AccessParallel circuits control temperature preference in Drosophila during ageing
The detection of environmental temperature and regulation of body temperature are integral determinants of behaviour for all animals. These functions become less efficient in aged animals, particularly during ...
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Article
Open AccessLarge-scale segmentation and tracing for neurons in Drosophila brain by Fast Automatically Structural Tracing Algorithm (FASTA)
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Article
Open AccessToward the Drosophila connectome: structural analysis of the brain network
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Article
Open AccessLoss of vesicular dopamine release precedes tauopathy in degenerative dopaminergic neurons in a Drosophila model expressing human tau
While a number of genome-wide association studies have identified microtubule-associated protein tau as a strong risk factor for Parkinson’s disease (PD), little is known about the mechanism through which huma...
