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Article
Epigenetic reprogramming of mtDNA and its etiology in mitochondrial diseases
Mitochondrial functionality and its regulation are tightly controlled through a balanced crosstalk between the nuclear and mitochondrial DNA interactions. Epigenetic signatures like methylation, hydroxymethyla...
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Article
Correction: Molecular Insights of Drug Resistance in Epilepsy: Multi-omics Unveil
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Article
Correction to: Neuroimaging Genomics a Predictor of Major Depressive Disorder (MDD)
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Article
Neuroimaging Genomics a Predictor of Major Depressive Disorder (MDD)
Depression is a complex psychiatric disorder influenced by various genetic and environmental factors. Strong evidence has established the contribution of genetic factors in depression through twin studies and ...
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Article
Molecular Insights of Drug Resistance in Epilepsy: Multi-omics Unveil
Epilepsy is a devastating neurological disorder mainly associated with impaired synchronic discharge that leads to sensory, motor, and psychomotor impairments. Till now, about 30 anti-seizure medications (ASMs...
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Article
Gene Expression Analysis in T2DM and Its Associated Microvascular Diabetic Complications: Focus on Risk Factor and RAAS Pathway
Prolonged hyperglycemic conditions in type 2 diabetes mellitus (T2DM) cause pathological and functional damage to many organs and tissues, including the kidneys, retina, skin, and neuronal tissues, resulting i...
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Article
Genetic variations in tumor-suppressor miRNA-encoding genes and their target genes: focus on breast cancer development and possible therapeutic strategies
MicroRNAs (miRNAs) negatively affect gene expression by binding to their specific mRNAs resulting in either mRNA destruction or translational repression. The aberrant expression of various miRNAs has been asso...
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Article
Current Update on Categorization of Migraine Subtypes on the Basis of Genetic Variation: a Systematic Review
Migraine is a complex neurovascular disorder that is characterized by severe behavioral, sensory, visual, and/or auditory symptoms. It has been labeled as one of the ten most disabling medical illnesses in the...
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Article
Genomic Variation Affecting MPV and PLT Count in Association with Development of Ischemic Stroke and Its Subtypes
Platelets play a significant role in the pathophysiology of ischemic stroke since they are involved in the formation of intravascular thrombus after erosion or rupture of the atherosclerotic plaques. Platelet ...
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Article
Oncogenic metabolic reprogramming in breast cancer: focus on signaling pathways and mitochondrial genes
Oncogenic metabolic reprogramming impacts the abundance of key metabolites that regulate signaling and epigenetics. Metabolic vulnerability in the cancer cell is evident from the Warburg effect. The research o...
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Article
Brain metastasis in breast cancer: focus on genes and signaling pathways involved, blood–brain barrier and treatment strategies
Breast cancer (BC) is one of the most prevalent types of cancer in women. Despite advancement in early detection and efficient treatment, recurrence and metastasis continue to pose a significant risk to the li...
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Article
Role of tRNA-Derived Fragments in Neurological Disorders: a Review
tRFs are small tRNA derived fragments that are emerging as novel therapeutic targets and regulatory molecules in the pathophysiology of various neurological disorders. These are derived from precursor or matur...
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Article
Advanced molecular therapies for neurological diseases: focus on stroke, alzheimer's disease, and parkinson's disease
Neurological diseases (NDs) are one of the leading causes of disability and the second leading cause of death globally. Among these stroke, Alzheimer's disease (AD), and Parkinson's disease (PD) are the most c...
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Article
Prognostic significance of CHAC1 expression in breast cancer
An emerging component of Unfolded Protein Response (UPR) pathway, cation transport regulator homolog 1 (CHAC1) has been conferred with the ability to degrade intracellular glutathione and induce apoptosis, how...
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Article
Role of Omics in Migraine Research and Management: A Narrative Review
Migraine is a neurological disorder defined by episodic attacks of chronic pain associated with nausea, photophobia, and phonophobia. It is known to be a complex disease with several environmental and genetic ...
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Article
Differential molecular mechanistic behavior of HDACs in cancer progression
Genetic aberration including mutation in oncogenes and tumor suppressor genes transforms normal cells into tumor cells. Epigenetic modifications work concertedly with genetic factors in controlling cancer deve...
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Article
Role of miRNAs in diabetic neuropathy: mechanisms and possible interventions
Accelerating cases of diabetes worldwide have given rise to higher incidences of diabetic complications. MiRNAs, a much-explored class of non-coding RNAs, play a significant role in the pathogenesis of diabete...
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Article
miRNA signatures in diabetic retinopathy and nephropathy: delineating underlying mechanisms
A worldwide failure to achieve glycemic targets has led to complications associated with diabetes mellitus. In addition to genetic and other risk factors, epigenetic factors like DNA methylation, histone modif...
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Reference Work Entry In depth
Targeting Redox Homeostasis of Tumor Cells by Therapeutic Compounds in Cancer
Cancer is one of the significant causes of morbidity and mortality in the world. The role of oxidative stress in tumor progression and metastasis has been under focus since the last two decades, suggesting the...
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Living Reference Work Entry In depth
Targeting Redox Homeostasis of Tumor Cells by Therapeutic Compounds in Cancer
Cancer is one of the significant causes of morbidity and mortality in the world. The role of oxidative stress in tumor progression and metastasis has been under focus since the last two decades, suggesting the...
