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Open AccessGenetic architecture of childhood speech disorder: a review
Severe speech disorders lead to poor literacy, reduced academic attainment and negative psychosocial outcomes. As early as the 1950s, the familial nature of speech disorders was recognized, implying a genetic ...
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Open AccessCorrection: Genetic aetiologies for childhood speech disorder: novel pathways co-expressed during brain development
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Open AccessGenetic aetiologies for childhood speech disorder: novel pathways co-expressed during brain development
Childhood apraxia of speech (CAS), the prototypic severe childhood speech disorder, is characterized by motor programming and planning deficits. Genetic factors make substantive contributions to CAS aetiology,...
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Article
Grey matter volume in developmental speech and language disorder
Developmental language disorder (DLD) and developmental speech disorder (DSD) are common, yet their etiologies are not well understood. Atypical volume of the inferior and posterior language regions and striat...
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Open AccessA set of regulatory genes co-expressed in embryonic human brain is implicated in disrupted speech development
Genetic investigations of people with impaired development of spoken language provide windows into key aspects of human biology. Over 15 years after FOXP2 was identified, most speech and language impairments rema...
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Patterns and Predictors of Language Development from 4 to 7 Years in Verbal Children With and Without Autism Spectrum Disorder
This study used a prospective community-based sample to describe patterns and predictors of language development from 4 to 7 years in verbal children (IQ ≥ 70) with autism spectrum disorder (ASD; n = 26–27). C...
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Open AccessEarly neuroimaging markers of FOXP2 intragenic deletion
FOXP2 is the major gene associated with severe, persistent, developmental speech and language disorders. While studies in the original family in which a FOXP2 mutation was found showed volume reduction and reduce...
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Article
Anatomy and lateralization of the human corticobulbar tracts: an fMRI-guided tractography study
The left hemisphere lateralization bias for language functions, such as syntactic processing and semantic retrieval, is well known. Although several theories and clinical data indicate a link between speech mo...
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Article
Consensus paper on post-operative pediatric cerebellar mutism syndrome: the Iceland Delphi results
Confusion has surrounded the description of post-operative mutism and associated morbidity in pediatric patients with cerebellar tumors for years. The heterogeneity of definitions and diagnostic features has h...
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Erratum to: New Genes for Focal Epilepsies with Speech and Language Disorders
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New Genes for Focal Epilepsies with Speech and Language Disorders
The last 2 years have seen exciting advances in the genetics of Landau-Kleffner syndrome and related disorders, encompassed within the epilepsy-aphasia spectrum (EAS). The striking finding of mutations in the N-m...
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Open AccessNeurobehaviour between birth and 40 weeks’ gestation in infants born <30 weeks’ gestation and parental psychological wellbeing: predictors of brain development and child outcomes
Infants born <30 weeks’ gestation are at increased risk of long term neurodevelopmental problems compared with term born peers. The predictive value of neurobehavioural examinations at term equivalent age in v...
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Incidence of mutism, dysarthria and dysphagia associated with childhood posterior fossa tumour
Dysarthria and dysphagia are known complications following posterior fossa tumour (PFT) surgery. Outcome studies for these disorders, however, have focused on a select sub-group of children with mutism. Little...
