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  1. No Access

    Article

    Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes

    Parkinson’s disease, the most common age-related movement disorder, is a progressive neurodegenerative disease with unclear etiology. Key neuropathological hallmarks are Lewy bodies and Lewy neurites: neuronal...

    Sarah H. Shahmoradian, Amanda J. Lewis, Christel Genoud… in Nature Neuroscience (2019)

  2. Article

    Open Access

    Characterization of Brain Lysosomal Activities in GBA-Related and Sporadic Parkinson’s Disease and Dementia with Lewy Bodies

    Mutations in the GBA gene, encoding the lysosomal hydrolase glucocerebrosidase (GCase), are the most common known genetic risk factor for Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). The present ...

    Tim E. Moors, Silvia Paciotti, Angela Ingrassia… in Molecular Neurobiology (2019)

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  3. Article

    Open Access

    Therapeutic potential of autophagy-enhancing agents in Parkinson’s disease

    Converging evidence from genetic, pathological and experimental studies have increasingly suggested an important role for autophagy impairment in Parkinson’s Disease (PD). Genetic studies have identified mutat...

    Tim E. Moors, Jeroen J. M. Hoozemans, Angela Ingrassia… in Molecular Neurodegeneration (2017)

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