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Article
Open AccessShort Telomere Syndrome presenting with pulmonary fibrosis, liver cirrhosis and hepatopulmonary syndrome: a case report
Idiopathic pulmonary fibrosis is thought to result from aberrant post-injury activation of epithelial cells leading to fibroblast proliferation and activation. A number of genetic aetiologies have been implica...
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Article
Open AccessOrthotopic Heart and Combined Heart Liver Transplantation: the Ultimate Treatment Option for Failing Fontan Physiology
This is a comprehensive update on failing Fontan physiology and the role of heart and combined heart and liver transplantation in the current era.
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Article
CHRFAM7A reduces monocyte/macrophage migration and colony formation in vitro
CHRFAM7A is a unique human gene that encodes a dominant negative inhibitor of the α7 nicotinic acetylcholine receptor. We have recently shown that CHRFAM7A is expressed in human leukocytes, increases cel–cell ...
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Chapter
Influences and Complications
The complexity of LUTS is greater when viewed in some of the contexts with which they are particularly associated. Mixed urinary incontinence reflects co-existence of both storage and voiding LUTS, each substa...
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Article
Open reading frame mining identifies a TLR4 binding domain in the primary sequence of ECRG4
The embedding of small peptide ligands within large inactive pre-pro-precursor proteins encoded by orphan open reading frames (ORFs) makes them difficult to identify and study. To address this problem, we gene...
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Chapter
Building the Multidisciplinary Transition Team
A major challenge arises in adolescent patients because ongoing care needs when entering young adulthood can be complex and far-reaching. The patient with a congenital and long-term condition is on a lifelong ...
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Article
Open AccessEffects of a novel peptide Ac-SDKP in radiation-induced coronary endothelial damage and resting myocardial blood flow
Cancer survivors treated with thoracic ionizing radiation are at higher risk of premature death due to myocardial ischemia. No therapy is currently available to prevent or mitigate these effects. We tested the...
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Article
Open AccessChoroid plexus genes for CSF production and brain homeostasis are altered in Alzheimer’s disease
The roles of the choroid plexus (CP) and cerebrospinal fluid (CSF) production have drawn increasing attention in Alzheimer’s disease (AD) research. Specifically, studies document markedly decreased CSF product...
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Article
Open AccessAvoid reinventing the wheel: implementation of the Ottawa Clinic Assessment Tool (OCAT) in Internal Medicine
Workplace based assessment (WBA) is crucial to competency-based education. The majority of healthcare is delivered in the ambulatory setting making the ability to run an entire clinic a crucial core competency...
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Article
Open AccessImpact of noncardiac findings in patients undergoing CT coronary angiography: a substudy of the Scottish computed tomography of the heart (SCOT-HEART) trial
Noncardiac findings are common on coronary computed tomography angiography (CCTA). We assessed the clinical impact of noncardiac findings, and potential changes to surveillance scans with the application of ne...
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Article
Open AccessComparative transcriptomics of choroid plexus in Alzheimer’s disease, frontotemporal dementia and Huntington’s disease: implications for CSF homeostasis
In Alzheimer’s disease, there are striking changes in CSF composition that relate to altered choroid plexus (CP) function. Studying CP tissue gene expression at the blood–cerebrospinal fluid barrier could prov...
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Article
Open AccessDiscovery of a Biological Mechanism of Active Transport through the Tympanic Membrane to the Middle Ear
Otitis media (OM) is a common pediatric disease for which systemic antibiotics are often prescribed. While local treatment would avoid the systemic treatment side-effects, the tympanic membrane (TM) represents...
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Article
Seismic performance of non-structural components and contents in buildings: an overview of NZ research
This paper summarizes the research on non-structural elements and building contents being conducted at University of Canterbury in New Zealand. Since the 2010-2011 series of Canterbury earthquakes, in which da...
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Article
Esophageal cancer-related gene-4 (ECRG4) interactions with the innate immunity receptor complex
The human c2orf40 gene encodes a tumor suppressor gene called esophageal cancer-related gene-4 (ECRG4) with pro- and anti-inflammatory activities that depend on cell surface processing. Here, we investigated ...
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Article
Open AccessA Human-Specific α7-Nicotinic Acetylcholine Receptor Gene in Human Leukocytes: Identification, Regulation and the Consequences of CHRFAM7A Expression
The human genome contains a variant form of the α7-nicotinic acetylcholine receptor (α7nAChR) gene that is uniquely human. This CHRFAM7A gene arose during human speciation and recent data suggests that its expres...
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Protocol
Vascular Normalization in Cerebral Angiogenesis: Friend or Foe?
Current antiangiogenic therapies have led to the observation that such agents can lead to improved tumor vessel structure and function termed “vascular normalization” which reduces tumor burden. However, vesse...
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Article
The candidate tumor suppressor gene Ecrg4 as a wound terminating factor in cutaneous injury
The Esophageal cancer-related gene-4 (Ecrg4) is a candidate tumor suppressor gene whose secreted protein product has been implicated in the development and progression of epithelial cancers, neuroprogenitor ce...
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Article
Open AccessRole of multidetector computed tomography in the diagnosis and management of patients attending the rapid access chest pain clinic, The Scottish computed tomography of the heart (SCOT-HEART) trial: study protocol for randomized controlled trial
Rapid access chest pain clinics have facilitated the early diagnosis and treatment of patients with coronary heart disease and angina. Despite this important service provision, coronary heart disease continues...
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Article
Cell-specific processing and release of the hormone-like precursor and candidate tumor suppressor gene product, Ecrg4
The human open reading frame C2orf40 encodes esophageal cancer-related gene-4 (Ecrg4), a newly recognized neuropeptide-like precursor protein whose gene expression by cells in vitro, over-expression in mice in...
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Article
Open AccessVagal Stimulation Modulates Inflammation through a Ghrelin Mediated Mechanism in Traumatic Brain Injury
Traumatic brain injury (TBI) releases a cascade of inflammatory cytokines. Vagal nerve stimulation (VNS) and ghrelin have known anti-inflammatory effects; furthermore, ghrelin release is stimulated by acetylch...
