14 Result(s)

Article

Lipid-induced transcriptomic changes in blood link to lipid metabolism and allergic response

Immune cell function can be altered by lipids in circulation, a process potentially relevant to lipid-associated inflammatory diseases including atherosclerosis and rheumatoid arthritis. To gain further insigh...

Koen F. Dekkers, Roderick C. Slieker, Andreea Ioan-Facsinay… in Nature Communications (2023)

Article

Hyaluronidase treatment of synovial fluid is required for accurate detection of inflammatory cells and soluble mediators

Synovial fluid (SF) is commonly used for diagnostic and research purposes, as it is believed to reflect the local inflammatory environment. Owing to its complex composition and especially the presence of hyalu...

Hilde Brouwers, Johannes Hendrick von Hegedus… in Arthritis Research & Therapy (2022)

Article

Lipid metabolism of leukocytes in the unstimulated and activated states

Lipidomics has emerged as a powerful technique to study cellular lipid metabolism. As the lipidome contains numerous isomeric and isobaric species resulting in a significant overlap between different lipid cla...

Juan Carlos Alarcon-Barrera… in Analytical and Bioanalytical Chemistry (2020)

Article

Lack of high BMI-related features in adipocytes and inflammatory cells in the infrapatellar fat pad (IFP)

Obesity is associated with the development and progression of osteoarthritis (OA). Although the infrapatellar fat pad (IFP) could be involved in this association, due to its intracapsular localization in the k...

Anja J. de Jong, Inge R. Klein-Wieringa, Stefan N. Andersen… in Arthritis Research & Therapy (2017)

Article

Differences in serum and synovial CD4+ T cells and cytokine profiles to stratify patients with inflammatory osteoarthritis and rheumatoid arthritis

The aim was to investigate CD4⁺T-cell subsets, immune cells and their cytokine profiles in blood and synovial compartments in rheumatoid arthritis (RA) and inflammatory osteoarthritis (OA) to define specific immu...

Alessandra Penatti, Federica Facciotti, Roberta De Matteis… in Arthritis Research & Therapy (2017)

Article

Acute phase inflammation is characterized by rapid changes in plasma/peritoneal fluid N-glycosylation in mice

Murine zymosan-induced peritonitis is a widely used model for studying the molecular and cellular events responsible for the initiation, persistence and/or resolution of inflammation. Among these events, it is...

Yoann Rombouts, Hulda S. Jónasdóttir, Agnes L. Hipgrave Ederveen… in Glycoconjugate Journal (2016)

Article

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and se...

Tuomas O. Kilpeläinen, Jayne F. Martin Carli, Alicja A. Skowronski… in Nature Communications (2016)

Article

Adiposity and hand osteoarthritis: the Netherlands Epidemiology of Obesity study

Obesity, usually characterized by the body mass index (BMI), is a risk factor for hand osteoarthritis (OA). We investigated whether adipose tissue and abdominal fat distribution are associated with hand OA.

A Willemien Visser, Andreea Ioan-Facsinay, Renée de Mutsert… in Arthritis Research & Therapy (2014)

Article

An emerging player in knee osteoarthritis: the infrapatellar fat pad

The role of inflammation in the development, progression, and clinical features of osteoarthritis has become an area of intense research in recent years. This led to the recognition of synovitis as an importan...

Andreea Ioan-Facsinay, Margreet Kloppenburg in Arthritis Research & Therapy (2013)

Article

Adipocytes from the infrapatellar fat pad of OA patients modulate CD4+ T cell cytokine production

Andreea Ioan-Facsinay, Joanneke C Kwekkeboom… in Journal of Translational Medicine (2011)