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Population pharmacokinetics of the dual endothelin receptor antagonist aprocitentan in subjects with or without essential or resistant hypertension
Aprocitentan is a novel, potent, dual endothelin receptor antagonist that recently demonstrated efficacy in the treatment of difficult-to-treat (resistant) hypertension. The aim of this study was to develop a ...
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Open AccessBefragung zu den Arbeits-, Weiterbildungs- und Forschungsbedingungen von Assistenzärztinnen und -ärzten in der internistisch-rheumatologischen Weiterbildung – BEWUSST
Daten zur Aus- und Weiterbildungssituation von Assistenzärzt:innen des Fachgebietes Innere Medizin und Rheumatologie liegen für das Bundesgebiet nicht vor. Aus diesem Grund initiierte die Kommission Fort- und ...
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Open AccessAktuelle Zahlen zur rheumatologischen Versorgung – Jahresbericht aus der Kerndokumentation der regionalen kooperativen Rheumazentren
Die Kerndokumentation der regionalen kooperativen Rheumazentren erfasst seit 1993 jährlich Daten zur rheumatologischen Versorgung von Patient:innen mit entzündlich-rheumatischen Erkrankungen. In diesem erstmal...
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Open AccessQuantifying the impact of key factors on the carbon mitigation potential of managed temperate forests
Forests mitigate climate change by reducing atmospheric \(\mathrm {CO_2}\) ...
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Correction to: Training the next generation of pharmacometric modelers: a multisector perspective
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Training the next generation of pharmacometric modelers: a multisector perspective
The current demand for pharmacometricians outmatches the supply provided by academic institutions and considerable investments are made to develop the competencies of these scientists on-the-job. Even with the...
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Open AccessSurvey on the working, training, and research conditions of resident physicians in internistic and rheumatological continuing education—BEWUSST
Data on the training and continuing education situation of residents in the field of internal medicine and rheumatology are not available for Germany. For this reason, the Commission for Education and Training...
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Open AccessAuthor Correction: Learning single-cell perturbation responses using neural optimal transport
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Open AccessLearning single-cell perturbation responses using neural optimal transport
Understanding and predicting molecular responses in single cells upon chemical, genetic or mechanical perturbations is a core question in biology. Obtaining single-cell measurements typically requires the cell...
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Open AccessBayesian optimization with safety constraints: safe and automatic parameter tuning in robotics
Selecting the right tuning parameters for algorithms is a pravelent problem in machine learning that can significantly affect the performance of algorithms. Data-efficient optimization algorithms, such as Baye...
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Open AccessRheumatologische Weiterbildungsstellen in Deutschland
In den nächsten Jahren gehen viele Haus- bzw. Fachärzt:innen in den Ruhestand. Wie in anderen Disziplinen stellt sich in der Rheumatologie die Frage, ob ausreichend Weiterbildungsstellen zur Verfügung stehen, ...
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Open AccessLimits in reaching the anhydrous state of wood and cellulose
Water-sorption studies and certain organic chemistry reactions require water removal from cellulosic samples. This is hindered by the strong interaction of cellulosic materials with water, and it remains uncer...
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Open AccessImpacts of land cover changes and global warming on climate in Colombia during ENSO events
Colombia is highly vulnerable to climate change which may be intensified due to the climatic effects of regional deforestation. Here, we quantify the impact of historical (1900–2011) land cover changes (LCC) a...
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Open AccessProduction of wood-based panel from recycled wood resource: a literature review
This article presents and discusses the available studies on utilization of waste wood (WW) resource for wood-based panel production. The cited literature indicated that the majority of WW research was from Eu...
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Open AccessInfluence of wood pretreatment, hardwood and softwood extractives on the compressive strength of fly ash-based geopolymer composite
This paper investigated the specific compressive strength (specific strength) of fly ash-based geopolymer composites with four hardwood extractives and two softwood extractives, as well as specific wood extrac...
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Zwei schwere Fälle von disseminiert-kutanen, nichttuberkulösen Mykobakteriosen durch Mycobacterium haemophilum
Mycobacterium (M.) haemophilum ist ein seltener Erreger aus der Gruppe der langsam wachsenden nichttuberkulösen Mykobakterien (NTM), der v. a. bei immunkompromittierten Patienten Krankheiten verursachen kann. Der...
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Open AccessQuantifying the impacts of land cover change on gross primary productivity globally
Historically, humans have cleared many forests for agriculture. While this substantially reduced ecosystem carbon storage, the impacts of these land cover changes on terrestrial gross primary productivity (GPP...
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Arthritiden und Lungenkavernen
Dieser Fallbericht beschreibt das sehr seltene gleichzeitige Auftreten einer rheumatoiden Arthritis und einer Granulomatose mit Polyangiitis mit der einzigen Organmanifestation lebensbedrohlicher Lungenkavität...
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Öffentlichkeitskampagne „rheuma2025“ des Bündnisses für Rheumatologie
Das Ziel der Öffentlichkeitskampagne „rheuma2025“ des Bündnisses für Rheumatologie ist die Verbesserung der Versorgung unserer Patienten. Dazu muss eine Zahl an Weiterbildungsstellen geschaffen werden, die dem...
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Bank demand for central bank liquidity and its impact on interbank markets
We develop a model of monetary policy implementation in which banks bid for liquidity provided by the central bank in fixed rate auctions, considering liquidity injections and extractions as well as the impact...
