23 Result(s)

Article

Pro-atrial natriuretic peptide is a prognostic marker in sepsis, similar to the APACHE II score: an observational study

Additional biomarkers in sepsis are needed to tackle the challenges of determining prognosis and optimizing selection of high-risk patients for application of therapy. In the present study, conducted in a coho...

Nils G Morgenthaler, Joachim Struck, Mirjam Christ-Crain, Andreas Bergmann… in Critical Care (2004)

Article

Erratum to: Pro-atrial natriuretic peptide is a prognostic marker in sepsis, similar to the APACHE II score: an observational study

Nils G Morgenthaler, Joachim Struck, Mirjam Christ-Crain, Andreas Bergmann… in Critical Care (2005)

Article

Mid-regional pro-adrenomedullin as a prognostic marker in sepsis: an observational study

Measurement of biomarkers is a potential approach to early assessment and prediction of mortality in patients with sepsis. The aim of the present study was to evaluate the prognostic value of mid-regional pro-...

Mirjam Christ-Crain, Nils G Morgenthaler, Joachim Struck, Stephan Harbarth… in Critical Care (2005)

Article

Pro-adrenomedullin to predict severity and outcome in community-acquired pneumonia [ISRCTN04176397]

Pro-adrenomedullin (proADM) is helpful for individual risk assessment and outcome prediction in sepsis. A major cause of sepsis is community-acquired pneumonia (CAP). The aim of this study was to investigate t...

Mirjam Christ-Crain, Nils G Morgenthaler, Daiana Stolz, Christian Müller… in Critical Care (2006)

Article

Midregional pro-Adrenomedullin in addition to b-type natriuretic peptides in the risk stratification of patients with acute dyspnea: an observational study

The identification of patients at highest risk for adverse outcome who are presenting with acute dyspnea to the emergency department remains a challenge. This study investigates the prognostic value of the new...

Mihael Potocki, Tobias Breidthardt, Tobias Reichlin, Nils G Morgenthaler… in Critical Care (2009)

Article

Copeptin and risk stratification in patients with acute dyspnea

The identification of patients at highest risk for adverse outcome who are presenting with acute dyspnea to the emergency department remains a challenge. This study investigates the prognostic value of Copepti...

Mihael Potocki, Tobias Breidthardt, Alexandra Mueller, Tobias Reichlin… in Critical Care (2010)

Article

Epitope specificity of anti-Adrenomedullin antibodies determines efficacy of mortality reduction in a cecal ligation and puncture mouse model

Adrenomedullin (ADM), a circulating vasodilatory peptide, plays an important role in the development of sepsis-associated hemodynamic and microcirculatory disorders. While administration of exogenous ADM had b...

Joachim Struck, Frauke Hein, Siegmund Karasch… in Intensive Care Medicine Experimental (2013)

Article

Adrenomedullin binding improves catecholamine responsiveness and kidney function in resuscitated murine septic shock

Adrenomedullin (ADM) has been referred to as a double-edged sword during septic shock: On one hand, ADM supplementation improved organ perfusion and function, attenuated systemic inflammation, and ultimately redu...

Katja Wagner, Ulrich Wachter, Josef A Vogt… in Intensive Care Medicine Experimental (2013)

Article

Plasma adrenomedullin is associated with short-term mortality and vasopressor requirement in patients admitted with sepsis

The incidence of death among patients admitted for severe sepsis or septic shock is high. Adrenomedullin (ADM) plays a central role in initiating the hyperdynamic response during the early stages of sepsis. Pi...

Rossella Marino, Joachim Struck, Alan S Maisel, Laura Magrini… in Critical Care (2014)

Article

Designing phase 3 sepsis trials: application of learned experiences from critical care trials in acute heart failure

Substantial attention and resources have been directed to improving outcomes of patients with critical illnesses, in particular sepsis, but all recent clinical trials testing various interventions or strategie...

Alexandre Mebazaa, Pierre François Laterre, James A. Russell… in Journal of Intensive Care (2016)

Article

Fasting levels of growth hormone are associated with carotid intima media thickness but are not affected by fluvastatin treatment

Growth hormone (GH) has been linked to cardiovascular disease but the exact mechanism of this association is still unclear. We here test if the fasting levels of GH are cross-sectionally associated with caroti...

Erik Hallengren, Peter Almgren, Maria Rosvall, Gerd Östling… in BMC Cardiovascular Disorders (2017)

Article

Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study

Adrenomedullin (ADM) regulates vascular tone and endothelial permeability during sepsis. Levels of circulating biologically active ADM (bio-ADM) show an inverse relationship with blood pressure and a direct re...

Alexandre Mebazaa, Christopher Geven, Alexa Hollinger, Xavier Wittebole… in Critical Care (2018)

Article

Proenkephalin and prognosis in heart failure with preserved ejection fraction: a GREAT network study

Proenkephalin (PENK), a stable endogenous opioid biomarker related to renal function, has prognostic utility in acute and chronic heart failure. We investigated the prognostic utility of PENK in heart failure ...

Prathap Kanagala, Iain B. Squire, Donald J. L. Jones… in Clinical Research in Cardiology (2019)

Article

Proenkephalin a 119–159 (penKid) – a novel biomarker for acute kidney injury in sepsis: an observational study

Sepsis is a leading cause of death worldwide and a major challenge for physicians to predict and manage. Proenkephalin A 119–159 (penKid) is a reliable surrogate marker for the more unstable endogenous opioid ...

Mari Rosenqvist, Kevin Bronton, Oliver Hartmann, Andreas Bergmann… in BMC Emergency Medicine (2019)

Article

Monitoring circulating dipeptidyl peptidase 3 (DPP3) predicts improvement of organ failure and survival in sepsis: a prospective observational multinational study

Dipeptidyl peptidase 3 (DPP3) is a cytosolic enzyme involved in the degradation of various cardiovascular and endorphin mediators. High levels of circulating DPP3 (cDPP3) indicate a high risk of organ dysfunct...

Alice Blet, Benjamin Deniau, Karine Santos, Dirk P. T. van Lier… in Critical Care (2021)

Article

Safety and tolerability of non-neutralizing adrenomedullin antibody adrecizumab (HAM8101) in septic shock patients: the AdrenOSS-2 phase 2a biomarker-guided trial

Investigate safety and tolerability of adrecizumab, a humanized monoclonal adrenomedullin antibody, in septic shock patients with high adrenomedullin.

Pierre-François Laterre, Peter Pickkers, Gernot Marx… in Intensive Care Medicine (2021)