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Article
Open AccessContinuous therapy response references for BCR::ABL1 monitoring in pediatric chronic myeloid leukemia
Response to tyrosine kinase inhibitor (TKI) therapy in patients with chronic myeloid leukemia (CML) is monitored by quantification of BCR::ABL1 transcript levels. Milestones for assessing optimal treatment respon...
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Article
Open AccessModelling the effect of demographic change and healthcare infrastructure on the patient structure in German hospitals – a longitudinal national study based on official hospital statistics
Effects of demographic change, such as declining birth rates and increasing individual life expectancy, require health system adjustments offering age- and needs-based care. In addition, healthcare factors can...
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Article
Open AccessImpact of BCR::ABL1 transcript type on RT-qPCR amplification performance and molecular response to therapy
Several studies have reported that chronic myeloid leukaemia (CML) patients expressing e14a2 BCR::ABL1 have a faster molecular response to therapy compared to patients expressing e13a2. To explore the reason for ...
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Article
Ranking of the most relevant hospital inpatient diagnoses by age and diagnostic group based on DRG statistics in Germany
Inpatient healthcare demand is influenced by demographic changes; however, existing research mainly focuses on age-related conditions among older age groups and lacks empirical evidence. We aimed to identify i...
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Article
Analysis of chronic myeloid leukaemia during deep molecular response by genomic PCR: a traffic light stratification model with impact on treatment-free remission
This work investigated patient-specific genomic BCR-ABL1 fusions as markers of measurable residual disease (MRD) in chronic myeloid leukaemia, with a focus on relevance to treatment-free remission (TFR) after ach...
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Article
Evaluation of polymorphisms in angiogenesis-related genes as predictive and prognostic markers for sunitinib-treated metastatic renal cell carcinoma patients
Single nucleotide polymorphisms (SNPs) in angiogenesis-associated genes might play an important role in activity of the tyrosine kinase inhibitor sunitinib and could affect survival of cancer patients treated ...
