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  1. Article

    Open Access

    MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis

    Aberrant expression of MYC transcription factor family members predicts poor clinical outcome in many human cancers. Oncogenic MYC profoundly alters metabolism and mediates an antioxidant response to maintain ...

    Hamed Alborzinia, Andrés F. Flórez, Sina Kreth, Lena M. Brückner… in Nature Cancer (2022)

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  2. No Access

    Chapter

    Ferroptosis: Concepts and Definitions

    Ferroptosis is a newly discovered form of cell death that is rapidly becoming associated to a variety of diseases and explaining their pathological mechanisms. This book addresses new emerging topics in the fi...

    Andrés F. Flórez, Hamed Alborzinia in Ferroptosis: Mechanism and Diseases (2021)

  3. Article

    Open Access

    Protein network prediction and topological analysis in Leishmania major as a tool for drug target selection

    Leishmaniasis is a virulent parasitic infection that causes a worldwide disease burden. Most treatments have toxic side-effects and efficacy has decreased due to the emergence of resistant strains. The outlook...

    Andrés F Flórez, Daeui Park, Jong Bhak, Byoung-Chul Kim… in BMC Bioinformatics (2010)

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