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Article
Engineering yeast phospholipid metabolism for de novo oleoylethanolamide production
Phospholipids, the most abundant membrane lipid components, are crucial in maintaining membrane structures and homeostasis for biofunctions. As a structurally diverse and tightly regulated system involved in m...
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Article
Metabolic engineering of Saccharomyces cerevisiae for production of germacrene A, a precursor of beta-elemene
Beta-elemene, a sesquiterpene and the major component of the medicinal herb Curcuma wenyu**, has antitumor activity against various types of cancer and could potentially serve as a potent antineoplastic drug. Ho...
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Article
Expanding the product portfolio of fungal type I fatty acid synthases
Integration of heterologous enzymes into the reaction chambers of fungal fatty acid synthases (FASs) demonstrates the capacity of these megaenzymes for engineered production of short- and medium-chain fatty ac...
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Article
Improving biobutanol production in engineered Saccharomyces cerevisiae by manipulation of acetyl-CoA metabolism
Recently, butanols (1-butanol, 2-butanol and iso-butanol) have generated attention as alternative gasoline additives. Butanols have several properties favorable in comparison to ethanol, and strong interest th...
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Article
Activation of the unfolded protein response during anoxia exposure in the turtle Trachemys scripta elegans
Red-eared slider turtles, Trachemys scripta elegans, can survive for several weeks without oxygen when submerged in cold water. We hypothesized that anaerobiosis is aided by adaptive up-regulation of the unfolded...
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Article
Epigenetics in anoxia tolerance: a role for histone deacetylases
The importance of epigenetics has been established in many key biological processes but the relevance of this regulatory mechanism to animal survival of low oxygen conditions has never been examined. To establ...
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Article
Regulation of the heat shock response under anoxia in the turtle, Trachemys scripta elegans
The effects of 20 h of anoxic submergence in cold water and 5 h of aerobic recovery on the heat shock response were analyzed in four organs of the anoxia-tolerant turtle Trachemys scripta elegans. Immunoblotting ...