12 Result(s)
within
Anastasia Krivoruchko
-
Article
Engineering yeast metabolism for the discovery and production of polyamines and polyamine analogues
Structurally complex and diverse polyamines and polyamine analogues are potential therapeutics and agrochemicals that can address grand societal challenges, for example, healthy ageing and sustainable food pro...
-
Article
Engineering yeast phospholipid metabolism for de novo oleoylethanolamide production
Phospholipids, the most abundant membrane lipid components, are crucial in maintaining membrane structures and homeostasis for biofunctions. As a structurally diverse and tightly regulated system involved in m...
-
Article
Open AccessCorrection: Author Correction: Metabolic engineering of Saccharomyces cerevisiae for production of very long chain fatty acid-derived chemicals
Nature Communications 8: Article number: 15587 (2017); Published: 26 May 2017, Updated: 13 July 2018 In the originally published version of this Article, financial support was not fully acknowledged. The PDF a...
-
Article
Metabolic engineering of Saccharomyces cerevisiae for production of germacrene A, a precursor of beta-elemene
Beta-elemene, a sesquiterpene and the major component of the medicinal herb Curcuma wenyu**, has antitumor activity against various types of cancer and could potentially serve as a potent antineoplastic drug. Ho...
-
Article
Open AccessMetabolic engineering of Saccharomyces cerevisiae for production of very long chain fatty acid-derived chemicals
Production of chemicals and biofuels through microbial fermentation is an economical and sustainable alternative for traditional chemical synthesis. Here we present the construction of a Saccharomyces cerevisiae ...
-
Article
Expanding the product portfolio of fungal type I fatty acid synthases
Integration of heterologous enzymes into the reaction chambers of fungal fatty acid synthases (FASs) demonstrates the capacity of these megaenzymes for engineered production of short- and medium-chain fatty ac...
-
Article
Open AccessModular pathway rewiring of Saccharomyces cerevisiae enables high-level production of L-ornithine
Baker’s yeast Saccharomyces cerevisiae is an attractive cell factory for production of chemicals and biofuels. Many different products have been produced in this cell factory by reconstruction of heterologous bio...
-
Article
Open AccessAdaptive mutations in sugar metabolism restore growth on glucose in a pyruvate decarboxylase negative yeast strain
A Saccharomyces cerevisiae strain carrying deletions in all three pyruvate decarboxylase (PDC) genes (also called Pdc negative yeast) represents a non-ethanol producing platform strain for the production of pyruv...
-
Article
Improving biobutanol production in engineered Saccharomyces cerevisiae by manipulation of acetyl-CoA metabolism
Recently, butanols (1-butanol, 2-butanol and iso-butanol) have generated attention as alternative gasoline additives. Butanols have several properties favorable in comparison to ethanol, and strong interest th...
-
Article
Activation of the unfolded protein response during anoxia exposure in the turtle Trachemys scripta elegans
Red-eared slider turtles, Trachemys scripta elegans, can survive for several weeks without oxygen when submerged in cold water. We hypothesized that anaerobiosis is aided by adaptive up-regulation of the unfolded...
-
Article
Epigenetics in anoxia tolerance: a role for histone deacetylases
The importance of epigenetics has been established in many key biological processes but the relevance of this regulatory mechanism to animal survival of low oxygen conditions has never been examined. To establ...
-
Article
Regulation of the heat shock response under anoxia in the turtle, Trachemys scripta elegans
The effects of 20 h of anoxic submergence in cold water and 5 h of aerobic recovery on the heat shock response were analyzed in four organs of the anoxia-tolerant turtle Trachemys scripta elegans. Immunoblotting ...
