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    Article

    Engineering yeast metabolism for the discovery and production of polyamines and polyamine analogues

    Structurally complex and diverse polyamines and polyamine analogues are potential therapeutics and agrochemicals that can address grand societal challenges, for example, healthy ageing and sustainable food pro...

    Jiufu Qin, Anastasia Krivoruchko, Boyang Ji, Yu Chen, Mette Kristensen in Nature Catalysis (2021)

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    Article

    Engineering yeast phospholipid metabolism for de novo oleoylethanolamide production

    Phospholipids, the most abundant membrane lipid components, are crucial in maintaining membrane structures and homeostasis for biofunctions. As a structurally diverse and tightly regulated system involved in m...

    Yi Liu, Quanli Liu, Anastasia Krivoruchko, Sakda Khoomrung in Nature Chemical Biology (2020)

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    Article

    Expanding the product portfolio of fungal type I fatty acid synthases

    Integration of heterologous enzymes into the reaction chambers of fungal fatty acid synthases (FASs) demonstrates the capacity of these megaenzymes for engineered production of short- and medium-chain fatty ac...

    Zhiwei Zhu, Yong** J Zhou, Anastasia Krivoruchko in Nature Chemical Biology (2017)

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    Open Access

    Adaptive mutations in sugar metabolism restore growth on glucose in a pyruvate decarboxylase negative yeast strain

    A Saccharomyces cerevisiae strain carrying deletions in all three pyruvate decarboxylase (PDC) genes (also called Pdc negative yeast) represents a non-ethanol producing platform strain for the production of pyruv...

    Yiming Zhang, Guodong Liu, Martin K M Engqvist in Microbial Cell Factories (2015)