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Article
Engineering yeast metabolism for the discovery and production of polyamines and polyamine analogues
Structurally complex and diverse polyamines and polyamine analogues are potential therapeutics and agrochemicals that can address grand societal challenges, for example, healthy ageing and sustainable food pro...
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Article
Engineering yeast phospholipid metabolism for de novo oleoylethanolamide production
Phospholipids, the most abundant membrane lipid components, are crucial in maintaining membrane structures and homeostasis for biofunctions. As a structurally diverse and tightly regulated system involved in m...
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Article
Expanding the product portfolio of fungal type I fatty acid synthases
Integration of heterologous enzymes into the reaction chambers of fungal fatty acid synthases (FASs) demonstrates the capacity of these megaenzymes for engineered production of short- and medium-chain fatty ac...
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Article
Open AccessAdaptive mutations in sugar metabolism restore growth on glucose in a pyruvate decarboxylase negative yeast strain
A Saccharomyces cerevisiae strain carrying deletions in all three pyruvate decarboxylase (PDC) genes (also called Pdc negative yeast) represents a non-ethanol producing platform strain for the production of pyruv...