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Article
Open AccessNovel indolic AMPK modulators induce vasodilatation through activation of the AMPK–eNOS–NO pathway
Endothelial adenosine monophosphate-activated protein kinase (AMPK) plays a critical role in the regulation of vascular tone through stimulating nitric oxide (NO) release in endothelial cells. Since obesity le...
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Article
Pharmacodynamic modelling of the effect of remifentanil using the Pupillary Pain Index
Using a targeted controlled infusion of remifentanil during total intravenous anesthesia, we investigated the effect-site concentrations of remifentanil that correlate with different values of the Pupillary Pa...
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Article
Open AccessBiochar amendment improves degraded pasturelands in Brazil: environmental and cost-benefit analysis
Most deforested lands in Brazil are occupied by low-productivity cattle ranching. Brazil is the second biggest meat producer worldwide and is projected to increase its agricultural output more than any other c...
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Article
Celia’s encephalopathy and c.974dupG in BSCL2 gene: a hidden change in a known variant
Celia’s encephalopathy (progressive encephalopathy with/without lipodystrophy (PELD)) is a childhood neurodegenerative disorder with a fatal prognosis before the age of 10, due to the variant c.985C>T in the BSCL...
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Article
Open AccessUse of machine learning to identify novel, behaviorally active antagonists of the insect odorant receptor co-receptor (Orco) subunit
Olfaction is a key component of the multimodal approach used by mosquitoes to target and feed on humans, spreading various diseases. Current repellents have drawbacks, necessitating development of more effecti...
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Chapter and Conference Paper
Customer Engagement in Social Network Brand Communities: Drivers and Impact on Brand Loyalty
Social networking sites (SNS) have become an ideal tool to develop customer engagement (CE) with brands, leading companies to invest increasingly on virtual communities and CE, using the number of likes and co...
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Article
Analysis of the Spanish CCR5-∆32 inventory of cord blood units: lower cell counts in homozygous donors
The possibility to use CCR5-∆32 umbilical cord blood to cure HIV infection in patients in need of a hematopoietic transplant has been suggested. The less stringent HLA compatibility needed in this type of transpl...
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Article
Open AccessIdentification of a novel 2-oxindole fluorinated derivative as in vivo antitumor agent for prostate cancer acting via AMPK activation
The key metabolic sensor adenosine monophosphate-dependent kinase (AMPK) has emerged as a promising therapeutic target for cancer prevention and treatment. Besides its role in energy homeostasis, AMPK blocks c...
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Article
A novel multivariate STeady-state index during general ANesthesia (STAN)
The assessment of the adequacy of general anesthesia for surgery, namely the nociception/anti-nociception balance, has received wide attention from the scientific community. Monitoring systems based on the fro...
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Article
Non classical Monocytes Levels, Increased by Subcutaneous Fat-Secretome, Are Associated with Less Rehospitalization after Heart Failure Admission
Differential monocyte subsets are increased in obesity and heart failure (HF). We studied their role as predictors of rehospitalization for HF and their regulation by adipose tissue. Monocyte subsets and body ...
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Article
Open AccessThe amyloid fold of Gad m 1 epitopes governs IgE binding
Amyloids are polymeric structural states formed from locally or totally unfolded protein chains that permit surface reorganizations, stability enhancements and interaction properties that are absent in the pre...
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Chapter and Conference Paper
Feature Extraction as Ellipse of Wild-Life Images
In this work we propose a new feature for automatic identification of individuals that belong to the species with spot patterns in their fur such as leopards, giraffes, cheetahs, and jaguars. We specifically w...
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Article
Effect of propofol and remifentanil on a somatosensory evoked potential indicator of pain perception intensity in volunteers
Somatosensory evoked potentials (SEPs) have been linked to noxious activation and stimulus intensity. In this exploratory study we investigated the impact of anaesthetic drugs on SEPs and pain ratings, to asse...
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Article
Open AccessRecombinant human leptin treatment in genetic lipodystrophic syndromes: the long-term Spanish experience
Lipodystrophies are a group of diseases mainly characterized by a loss of adipose tissue and frequently associated with insulin resistance, hypertriglyceridemia, and hepatic steatosis. In uncommon lipodystrop...
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Article
Reduced glutathione export during programmed cell death of Neurospora crassa
In a previous study, we demonstrated that staurosporine (STS) induces programmed cell death (PCD) in the fungus Neurospora crassa and that glutathione has the capability of inhibiting both STS-induced reactive ox...
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Protocol
Functional Assay of Mammalian and Insect Olfactory Receptors Using Xenopus Oocytes
The large number of olfactory receptors (ORs) expressed by various mammalian and insect species, as well as the large number of potential odorant ligands, has made the pairing of odorants with receptors (de-o...
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Article
Combined use of pharmacophoric models together with drug metabolism and genotoxicity “in silico” studies in the hit finding process
In this study we propose a virtual screening strategy based on the generation of a pharmacophore hypothesis, followed by an in silico evaluation of some ADME-TOX properties with the aim to apply it to the hit ...
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Article
Meiotic regulation of the CDK activator RINGO/Speedy by ubiquitin-proteasome-mediated processing and degradation
Xenopus RINGO/Speedy (XRINGO) is a potent inducer of oocyte meiotic maturation that can directly activate Cdk1 and Cdk2. Here, we show that endogenous XRINGO protein accumulates transiently during meiosis I entry...
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Chapter and Conference Paper
Impact of atmospheric NH3 deposition on plant growth and functioning — a case study with Brassica oleracea L.
Brassica oleracea L. (curly kale) was exposed to 0, 2, 4, 6 and 8 µl l−1 NH3 during one week and the impact on growth and N compounds was determined. Exposure to NH3 increased shoot biomass production at 2 and 4
