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Open AccessBone-organ axes: bidirectional crosstalk
In addition to its recognized role in providing structural support, bone plays a crucial role in maintaining the functionality and balance of various organs by secreting specific cytokines (also known as osteo...
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Article
Prediction model for develo** neuropsychiatric systemic lupus erythematosus in lupus patients
This study aimed to construct a predictive model for assessing the risk of development of neuropsychiatric systemic lupus erythematosus (NPSLE) among patients with SLE based on clinical, laboratory, and meteor...
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Article
Naoxueshu Oral Liquid Accelerates Post-Craniotomy Hematoma Absorption in Patients: An Open-Label, Multicenter, and Randomized Controlled Trial
To investigate whether Naoxueshu Oral Liquid (NXS) could promote hematoma absorption in post-craniotomy hematoma (PCH) patients.
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Article
Open AccessRelationship between the methylenetetrahydrofolate reductase (MTHFR) rs1801133 SNP and serum homocysteine levels of Zhuang hypertensive patients in the central region of Guangxi
The relationship between the methylenetetrahydrofolate reductase (MTHFR) single nucleotide polymorphism (SNP) and serum homocysteine (Hcy) levels or H-type hypertension in different populations is inconsistent. T...
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Open AccessTafamidis decreased cardiac amyloidosis deposition in patients with Ala97Ser hereditary transthyretin cardiomyopathy: a 12-month follow-up cohort study
Transthyretin cardiac cardiomyopathy (ATTR-CM) is a rare but life-threatening disease. Tafamidis is an effective treatment for patients with ATTR-CM, however its long-term effects on cardiac remodeling and car...
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Article
Arthroscopic modified Broström procedure achieved similar favorable short term outcomes to open procedure for chronic lateral ankle instability cases with generalized joint laxity
To compare the short-term clinical outcomes of the open versus arthroscopic modified Broström procedure in generalized joint laxity (GJL) patients.
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Open AccessGender-specific impacts of thigh skinfold thickness and grip strength for predicting osteoporosis in type 2 diabetes
Diabetes with co-existing bone fragility or osteoporosis is common in elderly patients, whereas is frequently underestimated.
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Open AccessUtilization of mental health services in relation to the intention to reduce chemsex behavior among clients from an integrated sexual health services center in Taiwan
The intention of chemsex-practicing gay and bisexual men and other men who have sex with men (GBMSM) to reduce their drug use is an important factor for the utilization of harm reduction services. This study a...
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A deep learning-based method for the diagnosis of vertebral fractures on spine MRI: retrospective training and validation of ResNet
To improve the performance of less experienced clinicians in the diagnosis of benign and malignant spinal fracture on MRI, we applied the ResNet50 algorithm to develop a decision support system.
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A systematic review and meta-analysis on prevalence of and risk factors associated with depression, anxiety and insomnia in infectious diseases, including COVID-19: a call to action
Infectious disease epidemics have become more frequent and more complex during the 21st century, posing a health threat to the general public and leading to psychological symptoms. The current study was designed ...
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Attitude towards hereditary cancer risk management among women with cancer in Taiwan
Risk management intentions prior to genetic counseling predict risk management uptake following genetic testing. Limited studies examined the attitude and understanding towards genetic counseling/testing in un...
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Article
Bioinformatics analyses of gene expression profile identify key genes and functional pathways involved in cutaneous lupus erythematosus
Lupus erythematosus is an autoimmune disease that causes damage to multiple organs ranging from skin lesions to systemic manifestations. Cutaneous lupus erythematosus (CLE) is a common type of lupus erythemato...
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Open AccessMET amplification identified by next-generation sequencing and its clinical relevance for MET inhibitors
MET amplification plays an important role in the development of non-small-cell lung cancer (NSCLC) either de novo or in resistance to epidermal growth factor receptor tyrosine–kinase inhibitor (EGFR-TKI) settings...
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Prevalence of posttraumatic stress disorder after infectious disease pandemics in the twenty-first century, including COVID-19: a meta-analysis and systematic review
Pandemics have become more frequent and more complex during the twenty-first century. Posttraumatic stress disorder (PTSD) following pandemics is a significant public health concern. We sought to provide a rel...
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Retinoblastoma in Taiwan: survival and clinical characteristics
To figure out the impact of national health insurance program and treatment modalities on the clinical outcomes of patients with retinoblastoma.
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Open AccessLRWD1 expression is regulated through DNA methylation in human testicular embryonal carcinoma cells
Sperm growth and maturation are correlated with the expression levels of Leucine-rich repeat and WD repeat-containing protein 1 (LRWD1), a widely expressed protein in the human testicles. The decrease in LRWD1...
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Open AccessExploring factors influencing the retention of nurses in a religious hospital in Taiwan: a cross-sectional quantitative study
Long-term deficits in the nursing labor force and high turnover rates are common in the Taiwanese medical industry. Little research has investigated the psychological factors associated with the retention of n...
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A review of the association between oral bacterial flora and obstructive sleep apnea–hypopnea syndrome comorbid with cardiovascular disease
Obstructive sleep apnea–hypopnea syndrome (OSAHS), a common sleep disorder, has been shown to be an independent risk factor for cardiovascular disease (CVD). Recent studies have focused on the important roles ...
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Open AccessSevere pre-eclamptic women with headache: is posterior reversible encephalopathy syndrome an associated concurrent finding?
A high incidence of posterior reversible encephalopathy syndrome (PRES) has been observed in women with eclampsia on imaging. However this association was documented mostly after convulsions occurred. This stu...
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Article
Altered expression of circular RNA in primary Sjögren’s syndrome
This study evaluated expression of circRNA in primary Sjögren’s syndrome (pSS) patients so as to find novel biomarkers for pSS screening and discussed possible role of circRNA in pSS. We also evaluated express...