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Article
Open AccessPen-drawn Marangoni swimmer
Pen-drawing is an intuitive, convenient, and creative fabrication method for delivering emergent and adaptive design to real devices. To demonstrate the application of pen-drawing to robot construction, we dev...
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Article
Epitranscriptomics of cancer microniches
In this Tools of the Trade article, Lee describes Select-seq, a novel method for generating epitranscriptomic data from microniches within the tumour. The author reveals how the method can be used to identify ...
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Article
Purification of multiplex oligonucleotide libraries by synthesis and selection
Complex oligonucleotide (oligo) libraries are essential materials for diverse applications in synthetic biology, pharmaceutical production, nanotechnology and DNA-based data storage. However, the error rates i...
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Chapter
Advances in Tumor Sampling and Sequencing in Breast Cancer and their Application in Precision Diagnostics and Therapeutics
Intra- and Inter-tumoral heterogeneity is one of the main hurdles in diagnosing and treating breast cancer. Selecting, sampling, and sequencing the samples appropriately provide unique opportunities in realizi...
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Chapter
Optics and Fluidics
The use of light in biotechnology has reversely enlightened the path for development in biosciences. In this chapter, the basic optical principles used in micro/nano systems for biological applications are exp...
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Article
Open AccessBarcode-free next-generation sequencing error validation for ultra-rare variant detection
The advent of next-generation sequencing (NGS) has accelerated biomedical research by enabling the high-throughput analysis of DNA sequences at a very low cost. However, NGS has limitations in detecting rare-f...
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Article
Open AccessPHLI-seq: constructing and visualizing cancer genomic maps in 3D by phenotype-based high-throughput laser-aided isolation and sequencing
Spatial map** of genomic data to tissue context in a high-throughput and high-resolution manner has been challenging due to technical limitations. Here, we describe PHLI-seq, a novel approach that enables hi...
