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  1. Article

    Open Access

    The lipolysis inhibitor acipimox reverses the cardiac phenotype induced by electronic cigarettes

    Electronic cigarettes (e-cigarettes) are a prevalent alternative to conventional nicotine cigarettes among smokers and people who have never smoked. Increased concentrations of serum free fatty acids (FFAs) ar...

    Jorge Espinoza-Derout, Jose Mari Luis Arambulo… in Scientific Reports (2023)

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  2. No Access

    Article

    Nicotine plus a high-fat diet triggers cardiomyocyte apoptosis

    Cigarette smoking is an important risk factor for diabetes, cardiovascular disease and non-alcoholic fatty liver disease. The health risk associated with smoking can be aggravated by obesity. Smoking might als...

    Indrani Sinha-Hikim, Theodore C. Friedman, Mark Falz… in Cell and Tissue Research (2017)

  3. Article

    Erratum to: Impact of Chromogranin A deficiency on catecholamine storage, catecholamine granule morphology and chromaffin cell energy metabolism in vivo

    Teresa Pasqua, Sumana Mahata, Gautam K. Bandyopadhyay… in Cell and Tissue Research (2016)

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  4. No Access

    Article

    Impact of Chromogranin A deficiency on catecholamine storage, catecholamine granule morphology and chromaffin cell energy metabolism in vivo

    Chromogranin A (CgA) is a prohormone and granulogenic factor in neuroendocrine tissues with a regulated secretory pathway. The impact of CgA depletion on secretory granule formation has been previously demonst...

    Teresa Pasqua, Sumana Mahata, Gautam K. Bandyopadhyay… in Cell and Tissue Research (2016)

  5. No Access

    Article

    Testosterone is essential for skeletal muscle growth in aged mice in a heterochronic parabiosis model

    As humans age, they lose both muscle mass and strength (sarcopenia). Testosterone, a circulating hormone, progressively declines in aging and is associated with loss of muscle mass and strength. The surgical j...

    Indranil Sinha, Amiya P. Sinha-Hikim, Amy J. Wagers… in Cell and Tissue Research (2014)

  6. No Access

    Article

    Minocycline suppresses oxidative stress and attenuates fetal cardiac myocyte apoptosis triggered by in utero cocaine exposure

    This study investigates the molecular mechanisms by which minocycline, a second generation tetracycline, prevents cardiac myocyte death induced by in utero cocaine exposure. Timed mated pregnant Sprague-Dawley...

    Indrani Sinha-Hikim, Ruoqing Shen, Ify Nzenwa, Robert Gelfand… in Apoptosis (2011)

  7. No Access

    Article

    Involvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in mice

    Apoptosis has been implicated as a mechanism of loss of muscle cells in normal aging and plays an important role in age-related sarcopenia. To test the hypothesis that caspase 2 and c-Jun NH2-terminal kinase (JNK...

    Melissa Braga, Amiya P. Sinha Hikim, Sanjit Datta, Monica G. Ferrini… in Apoptosis (2008)

  8. No Access

    Article

    Involvement of c-Jun NH2-terminal kinase and nitric oxide-mediated mitochondria-dependent intrinsic pathway signaling in cardiotoxin-induced muscle cell death: role of testosterone

    To test the hypothesis that c-Jun NH2-terminal kinase (JNK) and nitric oxide (NO)-mediated signaling plays an important role in muscle cell apoptosis, we examined the contribution of these molecules in muscle cel...

    Indrani Sinha-Hikim, Mellisa Braga, Ruoqing Shen, Amiya P. Sinha Hikim in Apoptosis (2007)

  9. No Access

    Chapter and Conference Paper

    Structure-Function Relationships in Somatic Cells of the Testis and Accessory Reproductive Glands

    Somatic cells of the male are key to the normal functioning of the male reproductive system. Their physiology has been extensively measured using endocrine and endocrine receptor assays, but until recently, li...

    Lonnie D. Russell, Amiya P. Sinha Hikim… in Function of Somatic Cells in the Testis (1994)