33 Result(s)
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Americo A. Migliaccio
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Article
Vestibulo-Ocular Reflex Short-Term Adaptation Is Halved After Compensation for Unilateral Labyrinthectomy
Several prior studies, including those from this laboratory, have suggested that vestibulo-ocular reflex (VOR) adaptation and compensation are two neurologically related mechanisms. We therefore hypothesised that...
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Article
A Once-Daily High Dose of Intraperitoneal Ascorbate Improves Vestibulo-ocular Reflex Compensation After Unilateral Labyrinthectomy in the Mouse
Ascorbate potentiates the response of nicotinic-acetylcholine-receptors containing α9 and α10 subunits found predominantly in the efferent systems of the inner ear, such as the efferent vestibular system (EVS)...
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Open AccessIncremental Velocity Error as a New Treatment in Vestibular Rehabilitation (INVENT VPT) Trial: study protocol for a randomized controlled crossover trial
A clinical pattern of damage to the auditory, visual, and vestibular sensorimotor systems, known as multi-sensory impairment, affects roughly 2% of the US population each year. Within the population of US mili...
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Article
Vergence increases the amplitude of lateral ocular vestibular evoked myogenic potentials
The angular and linear vestibulo-ocular reflex responses are greater when viewing near targets to compensate for the relatively larger translation of the eyes with respect to the target. Our aim was to measure...
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Human Vestibulo-Ocular Reflex Adaptation Reduces when Training Demand Variability Increases
One component of vestibular rehabilitation in patients with vestibulo-ocular reflex (VOR) hypofunction is gaze-stabilizing exercises that seek to increase (adapt) the VOR response. These prescribed home-based ...
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Article
The instantaneous training demand drives vestibulo-ocular reflex adaptation
The vestibulo-ocular reflex (VOR) maintains stable vision during rapid head rotations by rotating the eyes in the opposite direction to the head. The latency between onset of the head rotation and onset of the...
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Article
Retinal Image Slip Must Pass the Threshold for Human Vestibulo-Ocular Reflex Adaptation
We sought to determine whether repeated vestibulo-ocular reflex (VOR) adaptation training to increase the VOR gain (eye/head velocity) had a lasting effect in normal subjects and whether there was a retinal im...
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Advanced Vestibular Rehabilitation
Vestibular rehabilitation is a critical tool facilitating recovery after peripheral or central vestibular deficits. In this chapter, we will discuss state-of-the-art clinical practice strategies. We will focus...
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Article
Human Vestibulo-Ocular Reflex Adaptation Training: Time Beats Quantity
The vestibulo-ocular reflex (VOR) is the main gaze stabilising system during rapid head movements. The VOR is highly plastic and its gain (eye/head velocity) can be increased via training that induces an incre...
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Human Vestibulo-Ocular Reflex Adaptation: Consolidation Time Between Repeated Training Blocks Improves Retention
We sought to determine if separating vestibulo-ocular reflex (VOR) adaptation training into training blocks with a consolidation (rest) period in between repetitions would result in improved VOR adaptation and...
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Article
Optimal Human Passive Vestibulo-Ocular Reflex Adaptation Does Not Rely on Passive Training
The vestibulo-ocular reflex (VOR) is the main vision-stabilising system during rapid head movements in humans. A visual-vestibular mismatch stimulus can be used to train or adapt the VOR response because it in...
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Article
The Effect of Visual Contrast on Human Vestibulo-Ocular Reflex Adaptation
The vestibulo-ocular reflex (VOR) is the main retinal image stabilising mechanism during rapid head movement. When the VOR does not stabilise the world or target image on the retina, retinal image slip occurs ...
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Article
Core Body Temperature Effects on the Mouse Vestibulo-ocular Reflex
Core body temperature has been shown to affect vestibular end-organ and nerve afferents so that their resting discharge rate and sensitivity increase with temperature. Our aim was to determine whether these ch...
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Article
Open AccessTailored multifactorial intervention to improve dizziness symptoms and quality of life, balance and gait in dizziness sufferers aged over 50 years: protocol for a randomised controlled trial
Dizziness is a frequently reported symptom in older people that can markedly impair quality of life. This manuscript presents the protocol for a randomised controlled trial, which has the main objective of det...
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The effect of retinal image error update rate on human vestibulo-ocular reflex gain adaptation
The primary function of the angular vestibulo-ocular reflex (VOR) is to stabilise images on the retina during head movements. Retinal image movement is the likely feedback signal that drives VOR modification/...
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Article
Velocity-selective adaptation of the horizontal and cross-axis vestibulo-ocular reflex in the mouse
One commonly observed phenomenon of vestibulo-ocular reflex (VOR) adaptation is a frequency-selective change in gain (eye velocity/head velocity) and phase (relative timing between the vestibular stimulus and...
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Article
Visual contribution to the high-frequency human angular vestibulo-ocular reflex
The vestibulo-ocular reflex (VOR) acts to maintain images stable on the retina by rotating the eyes in exactly the opposite direction, but with equal magnitude, to head velocity. When viewing a near target, th...
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Article
Glycine Receptor Deficiency and Its Effect on the Horizontal Vestibulo-ocular Reflex: a Study on the SPD1J Mouse
Inhibition is critical in the pathways controlling the vestibulo-ocular reflex (VOR) and plays a central role in the precision, accuracy and speed of this important vestibular-mediated compensatory eye movemen...
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Article
Unilateral Adaptation of the Human Angular Vestibulo-Ocular Reflex
A recent study showed that the angular vestibulo-ocular reflex (VOR) can be better adaptively increased using an incremental retinal image velocity error signal compared with a conventional constant large velo...
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Article
Transmastoid galvanic stimulation does not affect the vergence-mediated gain increase of the human angular vestibulo-ocular reflex
Vergence is one of several viewing contexts that require an increase in the angular vestibular-ocular reflex (aVOR) response. A previous monkey study found that the vergence-mediated gain (eye/head velocity) i...
