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Article
Open AccessRelaxed targeting rules help PIWI proteins silence transposons
In eukaryotes, small RNA guides, such as small interfering RNAs and microRNAs, direct AGO-clade Argonaute proteins to regulate gene expression and defend the genome against external threats. Only animals make ...
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Article
Open AccessGTSF1 accelerates target RNA cleavage by PIWI-clade Argonaute proteins
Argonaute proteins use nucleic acid guides to find and bind specific DNA or RNA target sequences. Argonaute proteins have diverse biological functions and many retain their ancestral endoribonuclease activity,...
