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Open AccessA cross-sectional study of asymptomatic Plasmodium falciparum infection burden and risk factors in general population children in 12 villages in northern Uganda
Plasmodium falciparum malaria is an important cause of morbidity in northern Uganda. This study was undertaken to assess village-, household-, and individual-level risk factors of asymptomatic falciparum malaria ...
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Open Access“We were being treated like the Queen”: understanding trial factors influencing high paediatric malaria treatment adherence in western Kenya
Adherence to anti-malarial medication is highly variable but frequently suboptimal. Numerous interventions with a variety of methodological approaches have been implemented to address the problem. A recently c...
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Open AccessAge and geographic patterns of Plasmodium falciparum malaria infection in a representative sample of children living in Burkitt lymphoma-endemic areas of northern Uganda
Falciparum malaria is an important risk factor for African Burkitt lymphoma (BL), but few studies have evaluated malaria patterns in healthy BL-age children in populations where both diseases are endemic. To o...
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Open AccessEfficacy of text-message reminders on paediatric malaria treatment adherence and their post-treatment return to health facilities in Kenya: a randomized controlled trial
Short Message Service (SMS) reminders have been suggested as a potential intervention for improving adherence to medications and health facility attendance.
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Article
Open AccessThe past, present and future use of epidemiological intelligence to plan malaria vector control and parasite prevention in Uganda
An important prelude to develo** strategies to control infectious diseases is a detailed epidemiological evidence platform to target cost-effective interventions and define resource needs.
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Article
Open AccessThe affordable medicines facility-malaria—A success in peril
The Affordable Medicines Facility-malaria (AMFm) has put into place a bold financing plan for artemisinin-combination therapy in a pilot phase in seven countries covering half the population at risk of malaria...
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Open AccessClosing the access barrier for effective anti-malarials in the private sector in rural Uganda: consortium for ACT private sector subsidy (CAPSS) pilot study
Artemisinin-based combination therapy (ACT), the treatment of choice for uncomplicated falciparum malaria, is unaffordable and generally inaccessible in the private sector, the first port of call for most mala...
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Open AccessOvercoming the affordability barrier for effective and high quality life saving malaria medicines in the private sector in rural Uganda: the Consortium for ACT Private Sector Subsidy (CAPSS) pilot study
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Open AccessQuinine, an old anti-malarial drug in a modern world: role in the treatment of malaria
Quinine remains an important anti-malarial drug almost 400 years after its effectiveness was first documented. However, its continued use is challenged by its poor tolerability, poor compliance with complex do...
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Open AccessMonitoring antimalarial safety and tolerability in clinical trials: A case study from Uganda
New antimalarial regimens, including artemisinin-based combination therapies (ACTs), have been adopted widely as first-line treatment for uncomplicated malaria. Although these drugs appear to be safe and well-...
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Open AccessSafety and tolerability of combination antimalarial therapies for uncomplicated falciparum malaria in Ugandan children
Combination antimalarial therapy is recommended for the treatment of uncomplicated falciparum malaria in Africa; however, some concerns about the safety and tolerability of new regimens remain. This study compare...
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Open AccessCaregivers' perceived treatment failure in home-based management of fever among Ugandan children aged less than five years
Home-based management of fever (HBMF) could improve prompt access to antimalarial medicines for African children. However, the perception of treatment failure by caregivers has not been assessed.
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Open AccessPharmacovigilance of antimalarial treatment in Africa: is it possible?
Pharmacovigilance, defined as "the science and activities relating to the detection, assessment, understanding and prevention of adverse effects or any other possible drug related problem", is increasingly bei...