9 Result(s)
within
Ambroise Desfosses
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessThe assembly of the Mitochondrial Complex I Assembly complex uncovers a redox pathway coordination
The Mitochondrial Complex I Assembly (MCIA) complex is essential for the biogenesis of respiratory Complex I (CI), the first enzyme in the respiratory chain, which has been linked to Alzheimer’s disease (AD) p...
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Article
Open AccessStructural landscape of the respiratory syncytial virus nucleocapsids
Human Respiratory Syncytial Virus (HRSV) is a prevalent cause of severe respiratory infections in children and the elderly. The helical HRSV nucleocapsid is a template for the viral RNA synthesis and a scaffol...
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Article
Open AccessStructural basis of tankyrase activation by polymerization
The poly-ADP-ribosyltransferase tankyrase (TNKS, TNKS2) controls a wide range of disease-relevant cellular processes, including WNT–β-catenin signalling, telomere length maintenance, Hippo signalling, DNA dama...
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Article
Open AccessComplete structure of the chemosensory array core signalling unit in an E. coli minicell strain
Motile bacteria sense chemical gradients with transmembrane receptors organised in supramolecular signalling arrays. Understanding stimulus detection and transmission at the molecular level requires precise st...
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Article
Open AccessMolecular architecture and regulation of BCL10-MALT1 filaments
The CARD11-BCL10-MALT1 (CBM) complex triggers the adaptive immune response in lymphocytes and lymphoma cells. CARD11/CARMA1 acts as a molecular seed inducing BCL10 filaments, but the integration of MALT1 and t...
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Article
Open AccessRIP2 filament formation is required for NOD2 dependent NF-κB signalling
Activation of the innate immune pattern recognition receptor NOD2 by the bacterial muramyl-dipeptide peptidoglycan fragment triggers recruitment of the downstream adaptor kinase RIP2, eventually leading to NF-...
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Article
TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity
In budding yeast, glucose withdrawal, via the Rag GTPases, leads to TORC1 inhibition through its re-organization into a giant, vacuole-associated helix named a TOROID (TORC1 organized in inhibited domain).
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Article
Open AccessIn vitro assembly of the Rous Sarcoma Virus capsid protein into hexamer tubes at physiological temperature
During a proteolytically-driven maturation process, the orthoretroviral capsid protein (CA) assembles to form the convex shell that surrounds the viral genome. In some orthoretroviruses, including Rous Sarcoma...
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Article
Self-organization of the vesicular stomatitis virus nucleocapsid into a bullet shape
The typical bullet shape of Rhabdoviruses is thought to rely on the matrix protein for stabilizing the nucleocapsid coil. Here we scrutinize the morphology of purified and recombinant nucleocapsids of vesicula...
