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Article
Open AccessFTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell
Cancer stem cells (CSCs) are a small but critical cell population for cancer biology since they display inherent resistance to standard therapies and give rise to metastases. Despite accruing evidence establis...
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Article
Open AccessThe PIWI protein Aubergine recruits eIF3 to activate translation in the germ plasm
Piwi-interacting RNAs (piRNAs) and PIWI proteins are essential in germ cells to repress transposons and regulate mRNAs. In Drosophila, piRNAs bound to the PIWI protein Aubergine (Aub) are transferred maternally t...
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Article
Open AccessAn epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells
Cancer persister cells tolerate anticancer drugs and serve as the founders of acquired resistance and cancer relapse. Here we show that a subpopulation of BRAFV600 mutant melanoma cells that tolerates exposure to...
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Article
Open AccessThe ribosome, (slow) beating heart of cancer (stem) cell
The ribosome has long been considered as a consistent molecular factory, with a rather passive role in the translation process. Recent findings have shifted this obsolete view, revealing a remarkably complex a...
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Article
RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration
Structural synaptic plasticity and remodelling are features of the healthy adult brain and are seen during hibernation; a hibernation-inspired model of mouse cooling used to study synaptic regeneration has ide...
