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Article
Open AccessGenome-centric analysis of short and long read metagenomes reveals uncharacterized microbiome diversity in Southeast Asians
Despite extensive efforts to address it, the vastness of uncharacterized ‘dark matter’ microbial genetic diversity can impact short-read sequencing based metagenomic studies. Population-specific biases in geno...
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Article
Metagenome-wide association analysis identifies microbial determinants of post-antibiotic ecological recovery in the gut
Loss of diversity in the gut microbiome can persist for extended periods after antibiotic treatment, impacting microbiome function, antimicrobial resistance and probably host health. Despite widespread antibio...
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Article
Open AccessCartography of opportunistic pathogens and antibiotic resistance genes in a tertiary hospital environment
Although disinfection is key to infection control, the colonization patterns and resistomes of hospital-environment microbes remain underexplored. We report the first extensive genomic characterization of micr...
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Article
Hybrid metagenomic assembly enables high-resolution analysis of resistance determinants and mobile elements in human microbiomes
Characterization of microbiomes has been enabled by high-throughput metagenomic sequencing. However, existing methods are not designed to combine reads from short- and long-read technologies. We present a hybr...
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Article
Open AccessUnderstanding the microbial basis of body odor in pre-pubescent children and teenagers
Even though human sweat is odorless, bacterial growth and decomposition of specific odor precursors in it is believed to give rise to body odor in humans. While mechanisms of odor generation have been widely s...
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Article
Open AccessINC-Seq: accurate single molecule reads using nanopore sequencing
Nanopore sequencing provides a rapid, cheap and portable real-time sequencing platform with the potential to revolutionize genomics. However, several applications are limited by relatively high single-read err...
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Article
Whole metagenome profiling reveals skin microbiome-dependent susceptibility to atopic dermatitis flare
Whole metagenome analysis has the potential to reveal functional triggers of skin diseases, but issues of cost, robustness and sampling efficacy have limited its application. Here, we have established an alter...
