11 Result(s)

Article

Author Correction: ROR1 is upregulated in endometrial cancer and represents a novel therapeutic target

Dongli Liu, Kate Gunther, Luis A. Enriquez, Benjamin Daniels… in Scientific Reports (2022)

Article

ROR1 is upregulated in endometrial cancer and represents a novel therapeutic target

ROR1 and ROR2 are receptor tyrosine kinases with altered expression in a range of cancers. Silencing ROR1 or ROR2 in different tumour types has been shown to inhibit proliferation and decrease metastatic poten...

Dongli Liu, Kate Gunther, Luis A. Enriquez, Benjamin Daniels… in Scientific Reports (2020)

Article

Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers

Genome-wide association studies (GWAS) have led to the identification of hundreds of susceptibility loci across cancers, but the impact of further studies remains uncertain. Here we analyse summary-level data ...

Yan Dora Zhang, Amber N. Hurson, Haoyu Zhang… in Nature Communications (2020)

Article

Co-existence of leiomyomas, adenomyosis and endometriosis in women with endometrial cancer

Leiomyomas, adenomyosis, and endometriosis are reported to be risk factors for endometrial carcinoma (EC), and adenomyosis and endometriosis also for ovarian carcinoma (OC). We aimed to describe the prevalence...

Sharon E. Johnatty, Colin J. R. Stewart, Deborah Smith… in Scientific Reports (2020)

Article

Publisher Correction: Shared heritability and functional enrichment across six solid cancers

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

**a Jiang, Hilary K. Finucane, Fredrick R. Schumacher… in Nature Communications (2019)

Article

Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer

Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adip...

Manuel A. Ferreira, Eric R. Gamazon, Fares Al-Ejeh… in Nature Communications (2019)

Article

Shared heritability and functional enrichment across six solid cancers

Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types ba...

**a Jiang, Hilary K. Finucane, Fredrick R. Schumacher… in Nature Communications (2019)

Article

Germline pathogenic variants of 11 breast cancer genes in 7,051 Japanese patients and 11,241 controls

Pathogenic variants in highly penetrant genes are useful for the diagnosis, therapy, and surveillance for hereditary breast cancer. Large-scale studies are needed to inform future testing and variant classific...

Yukihide Momozawa, Yusuke Iwasaki, Michael T. Parsons… in Nature Communications (2018)

Article

Identification of nine new susceptibility loci for endometrial cancer

Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci f...

Tracy A. O’Mara, Dylan M. Glubb, Frederic Amant, Daniela Annibali… in Nature Communications (2018)

Article

Meta-analysis of gene expression studies in endometrial cancer identifies gene expression profiles associated with aggressive disease and patient outcome

Although endometrioid endometrial cancer (EEC; comprising ~80% of all endometrial cancers diagnosed) is typically associated with favourable patient outcome, a significant portion (~20%) of women with this sub...

Tracy A. O’Mara, Min Zhao, Amanda B. Spurdle in Scientific Reports (2016)