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  1. Article

    Open Access

    Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures

    Fragile X syndrome (FXS) is a neurodevelopmental disorder whose biochemical manifestations involve dysregulation of mGluR5-dependent pathways, which are widely modeled using cultured neurons. In vitro phenotyp...

    Daria Prilutsky, Alvin T. Kho, Nathan P. Palmer, Asha L. Bhakar… in Molecular Autism (2015)

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    Information Processing at the Genomics Level

    A central objective in biology is to identify and characterize the mechanistic underpinnings (e.g., gene, protein interactions) of a biological phenomenon (e.g., a phenotype). Today, it is technologically feas...

    Alvin T. Kho, Hongye Liu in Springer Handbook of Bio-/Neuroinformatics (2014)

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    Article

    Gene expression profiling of Duchenne muscular dystrophy skeletal muscle

    The primary cause of Duchenne muscular dystrophy (DMD) is a mutation in the dystrophin gene, leading to absence of the corresponding protein, disruption of the dystrophin-associated protein complex, and substa...

    Judith N. Haslett, Despina Sanoudou, Alvin T. Kho, Mei Han… in Neurogenetics (2003)