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Open AccessMRE11 liberates cGAS from nucleosome sequestration during tumorigenesis
Oncogene-induced replication stress generates endogenous DNA damage that activates cGAS–STING-mediated signalling and tumour suppression1–3. However, the precise mechanism of cGAS activation by endogenous DNA dam...
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Pre-operative Radiation and Immunotherapy in the Treatment of Non-metastatic Breast Cancer
To discuss the rationale and latest strategies for combining pre-operative radiation therapy (pre-op RT) and immunotherapy (IO) in the treatment of non-metastatic breast cancer.
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Regional Lymph Node Irradiation for Breast Cancer
Over recent years, inverse planned IMRT (intensity modulated radiation therapy) or VMAT (volumetric arc therapy) techniques have been increasingly incorporated into the management of breast cancer patients req...
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Current advances in immune checkpoint inhibitor combinations with radiation therapy or cryotherapy for breast cancer
Immune checkpoint inhibition (ICI) has demonstrated clinically significant efficacy when combined with chemotherapy in triple negative breast cancer (TNBC). Although many patients derived benefit, others do no...
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New Frontiers in Hypofractionation for Regional Nodal Irradiation in Breast Cancer
In recent years, there have been a number of small, yet notable practice changes in the delivery of postmastectomy radiation therapy (PMRT) in breast cancer patients. Herein, we describe the role of PMRT and i...
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Combining Radiation Therapy with Immune Checkpoint Blockadein Breast Cancer
Immune checkpoint blockade (ICB) is an emerging therapy in breast cancer. Its optimal integration with radiation therapy (RT) for breast cancer remains to be established. Herein, we review the current evidence...
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Open AccessReduction in low-dose to normal tissue with the addition of deep inspiration breath hold (DIBH) to volumetric modulated arc therapy (VMAT) in breast cancer patients with implant reconstruction receiving regional nodal irradiation
Despite dosimetric benefits of volumetric modulated arc therapy (VMAT) in breast cancer patients with implant reconstruction receiving regional nodal irradiation (RNI), low dose to the thoracic structures rema...
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Open AccessThe Abscopal Effect of Radiation Therapy: What Is It and How Can We Use It in Breast Cancer?
The abscopal effect refers to the ability of localized radiation to trigger systemic antitumor effects. Over the past 50 years, reports on the abscopal effect arising from conventional radiation have been rela...
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Black race as a prognostic factor in triple-negative breast cancer patients treated with breast-conserving therapy: a large, single-institution retrospective analysis
Triple-negative breast cancer (TNBC) disproportionately affects black women. However, black race as a prognostic factor in TNBC has not been well studied. We evaluated the effect of race, among other variables...
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Open AccessToxicity and outcomes of thoracic re-irradiation using stereotactic body radiation therapy (SBRT)
Patients treated for a thoracic malignancy carry a significant risk of develo** other lung lesions. Locoregional control of intrathoracic recurrences is challenging due to the impact of prior therapies on no...
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Open AccessStaying Cool Across the First Year of Middle School
As students transition into middle school they must successfully negotiate a new, larger peer context to attain or maintain high social standing. The goal of this study was to examine the extent to which the m...
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Social Motives Underlying Antisocial Behavior Across Middle School Grades
The goal of the study was to examine whether social motives (social mimicry, mutual attraction, and unreciprocated attraction) predict changes in antisocial behavior across middle school grades. The 2,003 init...
