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Article
Open AccessAbl depletion via autophagy mediates the beneficial effects of quercetin against Alzheimer pathology across species
Alzheimer’s disease is the most common age-associated neurodegenerative disorder and the most frequent form of dementia in our society. Aging is a complex biological process concurrently shaped by genetic, die...
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Article
Open AccessNeuroligin-mediated neurodevelopmental defects are induced by mitochondrial dysfunction and prevented by lutein in C. elegans
Complex-I-deficiency represents the most frequent pathogenetic cause of human mitochondriopathies. Therapeutic options for these neurodevelopmental life-threating disorders do not exist, partly due to the scar...
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Article
Open AccessThe flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species
Ageing constitutes the most important risk factor for all major chronic ailments, including malignant, cardiovascular and neurodegenerative diseases. However, behavioural and pharmacological interventions with...
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Chapter
Mitochondrial Longevity Pathways
This chapter describes our current knowledge of a fascinating class of C. elegans longevity mutants, the mitochondrial (Mit) mutants, whose lifespan extension is paradoxically triggered by interventions that dire...
