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Article
Open AccessMaternal psychosocial risk factors and child gestational epigenetic age in a South African birth cohort study
Accelerated epigenetic aging relative to chronological age has been found to be associated with higher risk of mortality in adults. However, little is known about whether and how in utero exposures might shape ch...
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Article
Open AccessSystematic evaluation of DNA methylation age estimation with common preprocessing methods and the Infinium MethylationEPIC BeadChip array
The capacity of technologies measuring DNA methylation (DNAm) is rapidly evolving, as are the options for applicable bioinformatics methods. The most commonly used DNAm microarray, the Illumina Infinium HumanM...
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Article
Open AccessDNA methylation as a predictor of fetal alcohol spectrum disorder
Fetal alcohol spectrum disorder (FASD) is a developmental disorder that manifests through a range of cognitive, adaptive, physiological, and neurobiological deficits resulting from prenatal alcohol exposure. A...
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Article
Open AccessChoice of surrogate tissue influences neonatal EWAS findings
Epigenomes are tissue specific and thus the choice of surrogate tissue can play a critical role in interpreting neonatal epigenome-wide association studies (EWAS) and in their extrapolation to target tissue. T...
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Article
Open AccessDNA methylation signatures of chronic alcohol dependence in purified CD3+ T-cells of patients undergoing alcohol treatment
Several studies have shown an association of alcohol dependence with DNA methylation (DNAm), suggesting that environmentally-induced changes on epigenomic variation may play an important role in alcohol depend...
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Article
Open AccessMaternal blood contamination of collected cord blood can be identified using DNA methylation at three CpGs
Cord blood is a commonly used tissue in environmental, genetic, and epigenetic population studies due to its ready availability and potential to inform on a sensitive period of human development. However, the ...
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Article
Open AccessDifferential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region
The Nicoya Peninsula in Costa Rica has one of the highest old-age life expectancies in the world, but the underlying biological mechanisms of this longevity are not well understood. As DNA methylation is hypot...
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Article
Open AccessDevelopmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome
Obesity is an escalating health problem worldwide, and hence the causes underlying its development are of primary importance to public health. There is growing evidence that suboptimal intrauterine environment...
