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A transgenic insertion upstream of Sox9 is associated with dominant XX sex reversal in the mouse

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  1. Article

    Open Access

    ML290 is a biased allosteric agonist at the relaxin receptor RXFP1

    Activation of the relaxin receptor RXFP1 has been associated with improved survival in acute heart failure. ML290 is a small molecule RXFP1 agonist with simple structure, long half-life and high stability. Her...

    Martina Kocan, Mohsin Sarwar, Sheng Y. Ang, **gbo **ao… in Scientific Reports (2017)

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  2. Article

    Open Access

    INPP4B protects from metabolic syndrome and associated disorders

    A high fat diet and obesity have been linked to the development of metabolic dysfunction and the promotion of multiple cancers. The causative cellular signals are multifactorial and not yet completely understo...

    Manqi Zhang, Yasemin Ceyhan, Elena M. Kaftanovskaya… in Communications Biology (2021)

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  3. Article

    Open Access

    Discovery of small molecule agonists of the Relaxin Family Peptide Receptor 2

    The relaxin/insulin-like family peptide receptor 2 (RXFP2) belongs to the family of class A G-protein coupled receptors (GPCRs) and it is the only known target for the insulin-like factor 3 peptide (INSL3). Th...

    Maria Esteban-Lopez, Kenneth J. Wilson, Courtney Myhr… in Communications Biology (2022)

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