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Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1

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    Open Access

    ML290 is a biased allosteric agonist at the relaxin receptor RXFP1

    Activation of the relaxin receptor RXFP1 has been associated with improved survival in acute heart failure. ML290 is a small molecule RXFP1 agonist with simple structure, long half-life and high stability. Her...

    Martina Kocan, Mohsin Sarwar, Sheng Y. Ang, **gbo **ao… in Scientific Reports (2017)

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