68 Result(s)
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Alexander Hapfelmeier
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Article
Open AccessIncidence and pattern of urgent revascularization in acute coronary syndromes treated with ticagrelor or prasugrel
The ISAR-REACT 5 trial compared the efficacy and safety of ticagrelor and prasugrel in patients with ACS managed invasively. The present study sought to investigate the impact of ticagrelor and prasugrel on th...
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Open AccessToo much time or not enough? An observational study of teacher wait time after questions in case-based seminars
We define teacher wait time (TWT) as a pause between a teacher question and the following response given by a student. TWT is valuable because it gives students time to activate prior knowledge and reflect on ...
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Open AccessLong-term prospective outcome data using EndoPredict as risk stratification and chemotherapy decision biomarker in hormone receptor-positive, HER2-negative early breast cancer
To report the prospective long-term outcome data of patients whose chemotherapy decision was guided by the EndoPredict test.
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Open AccessImpact of pre-existing mental health diagnoses on development of post-COVID and related symptoms: a claims data-based cohort study
This study aimed to examine the association of prior mental health diagnoses with the onset of Post-COVID-19 condition (PCC). We conducted a retrospective comparative cohort study and secondary analysis of rou...
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Article
Open AccessLow microsatellite instability: A distinct instability type in gastric cancer?
We recently showed that low microsatellite instability (MSI-L) is associated with a good response to platinum/5-fluorouracil (5-FU) neoadjuvant chemotherapy (CTx) in gastric cancer. The purpose of this study w...
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Open AccessMicrosatellite instability and sex-specific differences of survival in gastric cancer after neoadjuvant chemotherapy without and with taxane: An observational study in real world patients
To investigate the prognostic role of microsatellite instability (MSI) in association with sex of patients treated with platinum/fluoropyrimidine neoadjuvant chemotherapy (CTx) with or without a taxane-contai...
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Open AccessMedication Adherence and Healthcare Costs in Chronically Ill Patients Using German Claims Data
Despite the importance of medication adherence for chronically ill patients and the vast literature on its relationship to costs, this field suffers from methodological limitations. These are caused, amongst o...
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Open AccessTicagrelor or prasugrel in patients with acute coronary syndrome with off-hour versus on-hour presentation: a subgroup analysis of the ISAR-REACT 5 trial
To assess the efficacy and safety of ticagrelor versus prasugrel in patients with acute coronary syndrome (ACS) presenting during off- and on-hours.
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Article
Open AccessIs there an increase over time in the complexity of teacher questions and student responses in case-based clinical seminars? A cross-sectional video study
Case-based group discussions (CBGD) are a specific, interaction-focused format dedicated to fostering medical students’ skills in applying basic biomedical knowledge to patient cases. Existing conceptions of C...
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Article
Open AccessEffectiveness of an online education program for asthma patients in general practice: study protocol for a cluster randomized controlled trial
Asthma education programs (AEPs) have been shown to increase quality of life and reduce emergency treatments and hospital admissions. Despite the proven benefits, only a minority of asthma patients attend such...
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Open AccessThe Polyscore of autonomic parameters predicts mortality and identifies low-risk individuals among diabetic survivors of acute myocardial infarction
Survivors of an acute myocardial infarction with diabetes mellitus retain an increased mortality risk. Reliable assessment of individual risk is required for effective and cost-efficient medical care in these ...
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Open AccessCOVID-19 vaccine hesitancy in people with migratory backgrounds: a cross-sectional study among Turkish- and German-speaking citizens in Munich
This study aimed to investigate the knowledge, attitudes, behaviors, and COVID-19 vaccine hesitancy of people with migratory backgrounds among Turkish- and German-speaking patients in Munich.
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Open AccessDiverse ‘just-right’ levels of chromosomal instability and their clinical implications in neoadjuvant treated gastric cancer
The Cancer Genome Atlas (TCGA) consortium described EBV positivity(+), high microsatellite instability (MSI-H), genomic stability (GS) and chromosomal instability (CIN) as molecular subtypes in gastric carcino...
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Open AccessCOVID-19 assessment in family practice—A clinical decision rule based on self-rated symptoms and contact history
The study aimed to evaluate the diagnostic accuracy of contact history and clinical symptoms and to develop decision rules for ruling-in and ruling-out SARS-CoV-2 infection in family practice. We performed a p...
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Article
Open AccessPrediction of lung emphysema in COPD by spirometry and clinical symptoms: results from COSYCONET
Lung emphysema is an important phenotype of chronic obstructive pulmonary disease (COPD), and CT scanning is strongly recommended to establish the diagnosis. This study aimed to identify criteria by which phys...
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Article
ACT in Stroke (Anaesthesiological Care for Thrombectomy in Stroke)
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Article
Open AccessLifestyle modifications after the diagnosis of gynecological cancer
The influence of lifestyle factors on the quality of life, incidence and tumor recurrence has been evaluated in several studies and is gaining increasing importance in cancer research. However, the extent of t...
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Open AccessOn the optimistic performance evaluation of newly introduced bioinformatic methods
Most research articles presenting new data analysis methods claim that “the new method performs better than existing methods,” but the veracity of such statements is questionable. Our manuscript discusses and ...
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Article
Open AccessFirst prospective outcome data for the second-generation multigene test Endopredict in ER-positive/HER2-negative breast cancer
Prospectively collected outcome data of patients (pts) whose adjuvant systemic therapy recommendation was based on the clinico-molecular test EndoPredict® (EP) are presented.
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Article
Open AccessHybrid PET/MR imaging for the prediction of left ventricular recovery after percutaneous revascularisation of coronary chronic total occlusions
To evaluate myocardial viability assessment with hybrid 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography/magnetic resonance imaging ([18F]FDG-PET/MR) in predicting left ventricular (LV) wall motion re...
