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Article
A case of tubal endometriosis mimicking the appearances of tubal pregnancy at laparoscopy
Tubal pregnancy is a common gynaecological emergency. Due to the accuracy of transvaginal ultrasonography and serum human chorionic gonadotrophin (hCG) analysis is being managed more frequently by laparoscopy ...
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Article
Epidermal growth factor rescues trophoblast apoptosis induced by reactive oxygen species
Pre-eclampsia and intrauterine growth restriction are associated with increased apoptosis of placental villous trophoblast. This may result from placental hypoperfusion, leading to the generation of reactive o...
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Article
Intra-uterine growth restriction is associated with increased apoptosis and altered expression of proteins in the p53 pathway in villous trophoblast
Intrauterine growth restriction (IUGR) affects 3–8% of pregnancies and is associated with altered cell turnover in the villous trophoblast, an essential functional cell type of the human placenta. The intrinsi...
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The metabolome of human placental tissue: investigation of first trimester tissue and changes related to preeclampsia in late pregnancy
Unique biochemical and physical challenges to both mother and fetus are observed during human pregnancy, and the placenta plays an important role in protecting the fetus and supporting its development. Consequ...
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Article
Open AccessA structured review and exploration of the healthcare costs associated with stillbirth and a subsequent pregnancy in England and Wales
In contrast to other pregnancy complications the economic impact of stillbirth is poorly understood. We aimed to carry out a preliminary exploration of the healthcare costs of stillbirth from the time of pregn...
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Article
Open AccessThe Midland and North of England Stillbirth Study (MiNESS)
The United Kingdom has one of the highest rates of stillbirth in Europe, resulting in approximately 4,000 stillbirths every year. Potentially modifiable risk factors for late stillbirths are maternal age, obes...
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Article
Open AccessEvaluation of the quality of guidelines for the management of reduced fetal movements in UK maternity units
The development of evidence-based guidelines is a key step in ensuring that maternity care is of a universally high standard. To influence patient care national and international guidelines need to be interpre...
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Article
Open AccessAn international internet survey of the experiences of 1,714 mothers with a late stillbirth: the STARS cohort study
Stillbirth occurring after 28 weeks gestation affects between 1.5–4.5 per 1,000 births in high-income countries. The majority of stillbirths in this setting occur in women without risk factors. In addition, ma...
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Open AccessExploring the intangible economic costs of stillbirth
Compared to other pregnancy-related events, the full cost of stillbirth remains poorly described. In the UK one in every 200 births ends in stillbirth. As a follow-up to a recent study which explored the direc...
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Article
Open AccessFrom grief, guilt pain and stigma to hope and pride – a systematic review and meta-analysis of mixed-method research of the psychosocial impact of stillbirth
Despite improvements in maternity healthcare services over the last few decades, more than 2.7 million babies worldwide are stillborn each year. The global health agenda is silent about stillbirth, perhaps, in...
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Article
Open AccessQuantitative assessment of placental morphology may identify specific causes of stillbirth
Stillbirth is frequently the result of pathological processes involving the placenta. Understanding the significance of specific lesions is hindered by qualitative subjective evaluation. We hypothesised that q...
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Article
Open AccessPlacental PHLDA2 expression is increased in cases of fetal growth restriction following reduced fetal movements
Maternal perception of reduced fetal movements (RFM) is associated with increased risk of fetal growth restriction (FGR) and stillbirth, mediated by placental insufficiency. The maternally expressed imprinted ...
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Article
Open AccessCharacteristics of a global classification system for perinatal deaths: a Delphi consensus study
Despite the global burden of perinatal deaths, there is currently no single, globally-acceptable classification system for perinatal deaths. Instead, multiple, disparate systems are in use world-wide. This inc...
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Article
Open AccessClassification systems for causes of stillbirth and neonatal death, 2009–2014: an assessment of alignment with characteristics for an effective global system
To reduce the burden of 5.3 million stillbirths and neonatal deaths annually, an understanding of causes of deaths is critical. A systematic review identified 81 systems for classification of causes of stillbi...
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Open AccessSeeking order amidst chaos: a systematic review of classification systems for causes of stillbirth and neonatal death, 2009–2014
Each year, about 5.3 million babies die in the perinatal period. Understanding of causes of death is critical for prevention, yet there is no globally acceptable classification system. Instead, many disparate ...
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Open AccessStillbirth – a challenge for the 21st century
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Open AccessPlacental Dysfunction Underlies Increased Risk of Fetal Growth Restriction and Stillbirth in Advanced Maternal Age Women
Pregnancies in women of advanced maternal age (AMA) are susceptible to fetal growth restriction (FGR) and stillbirth. We hypothesised that maternal ageing is associated with utero-placental dysfunction, predis...
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Article
Open AccessStillbirth is associated with perceived alterations in fetal activity – findings from an international case control study
Stillbirth after 28 weeks gestation affects between 1.3–8.8 per 1000 births in high-income countries. The majority of stillbirths in this setting occur in women without established risk factors. Identification...
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Article
Open AccessSaving babies’ lives project impact and results evaluation (SPiRE): a mixed methodology study
Reducing stillbirth and early neonatal death is a national priority in the UK. Current evidence indicates this is potentially achievable through application of four key interventions within routine maternity c...
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Article
Open AccessWomen’s experiences of being invited to participate in a case-control study of stillbirth - findings from the Midlands and North of England Stillbirth Study
The Midlands and North of England Stillbirth Study (MiNESS) was a case-control study of women who had a stillbirth or who had an ongoing pregnancy. During the set up phase questions were raised about whether i...