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  1. Article

    A case of tubal endometriosis mimicking the appearances of tubal pregnancy at laparoscopy

    Tubal pregnancy is a common gynaecological emergency. Due to the accuracy of transvaginal ultrasonography and serum human chorionic gonadotrophin (hCG) analysis is being managed more frequently by laparoscopy ...

    Alexander E. P. Heazell, James B. Davis, Nighat R. Bhatti in Gynecological Surgery (2004)

  2. No Access

    Article

    Epidermal growth factor rescues trophoblast apoptosis induced by reactive oxygen species

    Pre-eclampsia and intrauterine growth restriction are associated with increased apoptosis of placental villous trophoblast. This may result from placental hypoperfusion, leading to the generation of reactive o...

    Sarah J. Moll, Carolyn J. P. Jones, Ian P. Crocker, Philip N. Baker in Apoptosis (2007)

  3. No Access

    Article

    Intra-uterine growth restriction is associated with increased apoptosis and altered expression of proteins in the p53 pathway in villous trophoblast

    Intrauterine growth restriction (IUGR) affects 3–8% of pregnancies and is associated with altered cell turnover in the villous trophoblast, an essential functional cell type of the human placenta. The intrinsi...

    Alexander E. P. Heazell, Andrew N. Sharp, Philip N. Baker, Ian P. Crocker in Apoptosis (2011)

  4. No Access

    Article

    The metabolome of human placental tissue: investigation of first trimester tissue and changes related to preeclampsia in late pregnancy

    Unique biochemical and physical challenges to both mother and fetus are observed during human pregnancy, and the placenta plays an important role in protecting the fetus and supporting its development. Consequ...

    Warwick B. Dunn, Marie Brown, Stephanie A. Worton, Kyle Davies in Metabolomics (2012)

  5. Article

    Open Access

    A structured review and exploration of the healthcare costs associated with stillbirth and a subsequent pregnancy in England and Wales

    In contrast to other pregnancy complications the economic impact of stillbirth is poorly understood. We aimed to carry out a preliminary exploration of the healthcare costs of stillbirth from the time of pregn...

    Hema Mistry, Alexander E P Heazell, Oluwaseyi Vincent in BMC Pregnancy and Childbirth (2013)

  6. Article

    Open Access

    The Midland and North of England Stillbirth Study (MiNESS)

    The United Kingdom has one of the highest rates of stillbirth in Europe, resulting in approximately 4,000 stillbirths every year. Potentially modifiable risk factors for late stillbirths are maternal age, obes...

    Jayne Platts, Edwin A Mitchell, Tomasina Stacey in BMC Pregnancy and Childbirth (2014)

  7. Article

    Open Access

    Evaluation of the quality of guidelines for the management of reduced fetal movements in UK maternity units

    The development of evidence-based guidelines is a key step in ensuring that maternity care is of a universally high standard. To influence patient care national and international guidelines need to be interpre...

    Stephanie Jokhan, Melissa K Whitworth, Felicity Jones in BMC Pregnancy and Childbirth (2015)

  8. Article

    Open Access

    An international internet survey of the experiences of 1,714 mothers with a late stillbirth: the STARS cohort study

    Stillbirth occurring after 28 weeks gestation affects between 1.5–4.5 per 1,000 births in high-income countries. The majority of stillbirths in this setting occur in women without risk factors. In addition, ma...

    Jane Warland, Louise M. O’Brien, Alexander E. P. Heazell in BMC Pregnancy and Childbirth (2015)

  9. Article

    Open Access

    Exploring the intangible economic costs of stillbirth

    Compared to other pregnancy-related events, the full cost of stillbirth remains poorly described. In the UK one in every 200 births ends in stillbirth. As a follow-up to a recent study which explored the direc...

    Chidubem B. Ogwulu, Louise J. Jackson in BMC Pregnancy and Childbirth (2015)

  10. Article

    Open Access

    From grief, guilt pain and stigma to hope and pride – a systematic review and meta-analysis of mixed-method research of the psychosocial impact of stillbirth

    Despite improvements in maternity healthcare services over the last few decades, more than 2.7 million babies worldwide are stillborn each year. The global health agenda is silent about stillbirth, perhaps, in...

    Christy Burden, Stephanie Bradley, Claire Storey in BMC Pregnancy and Childbirth (2016)

  11. Article

    Open Access

    Quantitative assessment of placental morphology may identify specific causes of stillbirth

    Stillbirth is frequently the result of pathological processes involving the placenta. Understanding the significance of specific lesions is hindered by qualitative subjective evaluation. We hypothesised that q...

    Imogen Ptacek, Anna Smith, Ainslie Garrod, Sian Bullough in BMC Clinical Pathology (2016)

  12. Article

    Open Access

    Placental PHLDA2 expression is increased in cases of fetal growth restriction following reduced fetal movements

    Maternal perception of reduced fetal movements (RFM) is associated with increased risk of fetal growth restriction (FGR) and stillbirth, mediated by placental insufficiency. The maternally expressed imprinted ...

    Anna Bugge Janssen, Simon J. Tunster, Alexander E. P. Heazell in BMC Medical Genetics (2016)

  13. Article

    Open Access

    Characteristics of a global classification system for perinatal deaths: a Delphi consensus study

    Despite the global burden of perinatal deaths, there is currently no single, globally-acceptable classification system for perinatal deaths. Instead, multiple, disparate systems are in use world-wide. This inc...

    Aleena M. Wojcieszek, Hanna E. Reinebrant in BMC Pregnancy and Childbirth (2016)

  14. Article

    Open Access

    Classification systems for causes of stillbirth and neonatal death, 2009–2014: an assessment of alignment with characteristics for an effective global system

    To reduce the burden of 5.3 million stillbirths and neonatal deaths annually, an understanding of causes of deaths is critical. A systematic review identified 81 systems for classification of causes of stillbi...

    Susannah Hopkins Leisher, Zheyi Teoh, Hanna Reinebrant in BMC Pregnancy and Childbirth (2016)

  15. Article

    Open Access

    Seeking order amidst chaos: a systematic review of classification systems for causes of stillbirth and neonatal death, 2009–2014

    Each year, about 5.3 million babies die in the perinatal period. Understanding of causes of death is critical for prevention, yet there is no globally acceptable classification system. Instead, many disparate ...

    Susannah Hopkins Leisher, Zheyi Teoh, Hanna Reinebrant in BMC Pregnancy and Childbirth (2016)

  16. Article

    Open Access

    Stillbirth – a challenge for the 21st century

    Alexander E. P. Heazell in BMC Pregnancy and Childbirth (2016)

  17. Article

    Open Access

    Placental Dysfunction Underlies Increased Risk of Fetal Growth Restriction and Stillbirth in Advanced Maternal Age Women

    Pregnancies in women of advanced maternal age (AMA) are susceptible to fetal growth restriction (FGR) and stillbirth. We hypothesised that maternal ageing is associated with utero-placental dysfunction, predis...

    Samantha C. Lean, Alexander E. P. Heazell, Mark R. Dilworth in Scientific Reports (2017)

  18. Article

    Open Access

    Stillbirth is associated with perceived alterations in fetal activity – findings from an international case control study

    Stillbirth after 28 weeks gestation affects between 1.3–8.8 per 1000 births in high-income countries. The majority of stillbirths in this setting occur in women without established risk factors. Identification...

    Alexander E. P. Heazell, Jane Warland, Tomasina Stacey in BMC Pregnancy and Childbirth (2017)

  19. Article

    Open Access

    Saving babies’ lives project impact and results evaluation (SPiRE): a mixed methodology study

    Reducing stillbirth and early neonatal death is a national priority in the UK. Current evidence indicates this is potentially achievable through application of four key interventions within routine maternity c...

    Kate Widdows, Holly E. Reid, Stephen A. Roberts in BMC Pregnancy and Childbirth (2018)

  20. Article

    Open Access

    Women’s experiences of being invited to participate in a case-control study of stillbirth - findings from the Midlands and North of England Stillbirth Study

    The Midlands and North of England Stillbirth Study (MiNESS) was a case-control study of women who had a stillbirth or who had an ongoing pregnancy. During the set up phase questions were raised about whether i...

    Jayne Budd, Tomasina Stacey, Bill Martin, Devender Roberts in BMC Pregnancy and Childbirth (2018)

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