T-Helper Cells
Methods and Protocols
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Article
Disseminated nocardiosis and anti-GM-CSF antibodies
Infections that are unusually severe or caused by opportunistic pathogens are a hallmark of primary immunodeficiency (PID). Anti-cytokine autoantibodies (ACA) are an emerging cause of acquired immunodeficiency...
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Open AccessColorectal neoplastic emergencies in immunocompromised patients: preliminary result from the Web-based International Register of Emergency Surgery and Trauma (WIRES-T trial)
Association of advanced age, neoplastic disease and immunocompromission (IC) may lead to surgical emergencies. Few data exist about this topic. Present study reports the preliminary data from the WIRES-T trial...
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Open AccessLaparoscopic versus open repair of perforated peptic ulcers: analysis of outcomes and identification of predictive factors of conversion
The surgical treatment for perforated peptic ulcers (PPUs) can be safely performed laparoscopically. This study aimed to compare the outcomes of patients who received different surgical approaches for PPU and ...
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Chapter
Acute Colonic Diverticulitis
The proper mini-invasive management of acute colonic diverticulitis (ACD) continues to be a matter of discussion for decades. However, the improvements in the effectiveness of antibiotic treatments, methods of...
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Open AccessLong-term SARS-CoV-2 Asymptomatic Carriage in an Immunocompromised Host: Clinical, Immunological, and Virological Implications
SARS-CoV-2 infection in immunocompromised hosts is challenging, and prolonged viral shedding can be a common complication in these patients. We describe the clinical, immunological, and virological course of a...
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Open AccessClinical and Immunological Features of SARS-CoV-2 Breakthrough Infections in Vaccinated Individuals Requiring Hospitalization
Waning immunity and the surge of SARS-CoV-2 variants are responsible for breakthrough infections, i.e., infections in fully vaccinated individuals. Although the majority of vaccinated infected subjects report ...
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Targeting immune checkpoints in juvenile idiopathic arthritis: accumulating evidence
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T Cell Delivery of Nanoparticles-Bound Anti-CD20 Monoclonal Antibody: Successful B Cell Depletion in the Spinal Cord during Experimental Autoimmune Encephalomyelitis
We developed a nanotechnology based-cell mediated drug delivery system by loading myelin antigen-specific T cells with nanoparticles bound to anti-CD20 monoclonal antibody. Anti-CD20 antibody is a current trea...
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Open AccessCompassionate use of JAK1/2 inhibitor ruxolitinib for severe COVID-19: a prospective observational study
Overwhelming inflammatory reactions contribute to respiratory distress in patients with COVID-19. Ruxolitinib is a JAK1/JAK2 inhibitor with potent anti-inflammatory properties. We report on a prospective, obse...
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Protocol
Human T-Cell Cloning by Limiting Dilution
T cells represent a heterogeneous population, including cells with different phenotypical and function properties. Despite, in the last years, several technologies were developed to investigate phenotypical p...
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Protocol
Study of Signal Transduction Pathways by Phospho-Protein Evaluation
Flow cytometric evaluation of status of signal molecules is a useful method to study T-cell signaling . As mutations occurring in TCR complex molecules, common gamma chain family’s , their receptors or ...
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Protocol
Human and Murine T-Helper Cell Recovery from Organs and Tissues
Isolation of cells from organs and tissues represents a challenge for many researchers. Cell yield, purity, and cell death are common problems associated with it, which greatly affect experimental results in t...
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Article
Risk factors for intra-abdominal abscess following laparoscopic appendectomy for acute appendicitis: a retrospective cohort study on 2076 patients
Intra-abdominal abscesses (IAA) may develop after laparoscopic appendectomies (LA) for acute appendicitis. The identification of risk factors for postoperative IAA could lead to a decrease in the readmission r...
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Disseminated Mycobacterium xenopi in an Adult with IL-12Rβ1 Deficiency
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Open AccessSphingosine Kinases promote IL-17 expression in human T lymphocytes
Sphingosine 1-phosphate (S1P) has a role in many cellular processes. S1P is involved in cell growth and apoptosis, regulation of cell trafficking, production of cytokines and chemokines. The kinases SphK1 and ...
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Article
Open AccessChitinase 3-like-1 is produced by human Th17 cells and correlates with the level of inflammation in juvenile idiopathic arthritis patients
CHI3L1 is a chitinase-like protein without enzymatic activity, produced by activated macrophages, chondrocytes, neutrophils. Recent studies on arthritis, asthma, and inflammatory bowel diseases suggest that ch...
