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  1. Article

    Open Access

    A metal-free salalen ligand with anti-tumor and synergistic activity in resistant leukemia and solid tumor cells via mitochondrial pathway

    Since the discovery of the well-known cis-platin, transition metal complexes are highly recognized as cytostatic agents. However, toxic side effects of the metal ions present in the complexes may pose signific...

    Sina M. Hopff, Qifang Wang, Corazon Frias… in Journal of Cancer Research and Clinical On… (2021)

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  2. No Access

    Article

    Sensitizing multidrug-resistant leukemia cells to common cytostatics by an aluminium-salen complex that has high-apoptotic effects in leukemia, lymphoma and mamma carcinoma cells

    We investigated the aluminium-salen complex MBR-8 as a potential anti-cancer agent. To see apoptotic effects induced by MBR-8, alone and in combination with common cytostatic drugs, DNA-fragmentations were studie...

    Sina M. Hopff, Liliane A. Onambele, Marc Brandenburg, Albrecht Berkessel… in BioMetals (2021)

  3. Article

    Open Access

    Salicylic diamines selectively eliminate residual undifferentiated cells from pluripotent stem cell-derived cardiomyocyte preparations

    Clinical translation of pluripotent stem cell (PSC) derivatives is hindered by the tumorigenic risk from residual undifferentiated cells. Here, we identified salicylic diamines as potent agents exhibiting toxi...

    Karsten Burkert, Hadiseh Taheri, Sarkawt Hamad, Matteo Oliverio… in Scientific Reports (2021)

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  4. No Access

    Article

    Efficient epoxidation over dinuclear sites in titanium silicalite-1

    Titanium silicalite-1 (TS-1) is a zeolitic material with MFI framework structure, in which 1 to 2 per cent of the silicon atoms are substituted for titanium atoms. It is widely used in industry owing to its ab...

    Christopher P. Gordon, Hauke Engler, Amadeus Samuel Tragl, Milivoj Plodinec… in Nature (2020)

  5. No Access

    Article

    Metal-free salan-type compound induces apoptosis and overcomes multidrug resistance in leukemic and lymphoma cells in vitro

    We report on our preclinical findings of a simple salicylic diamine compound (THG 1213) which has yielded exceptional results as a potential chemotherapeutic drug. THG 1213 is an easy to synthesize chiral and ...

    Maxim Dragoun, Thomas Günther, Corazon Frias… in Journal of Cancer Research and Clinical On… (2018)

  6. No Access

    Chapter

    Noncovalent Organocatalysis Based on Hydrogen Bonding: Elucidation of Reaction Paths by Computational Methods

    In this article, the functions of hydrogen bonds in organocatalytic reactions are discussed on atomic level by presenting DFT studies of selected examples. Theoretical investigation provides a detailed insight...

    Kerstin Etzenbach-Effers, Albrecht Berkessel in Asymmetric Organocatalysis (2009)

  7. No Access

    Article

    Stereoselective Michael Addition of Carbonyl Compounds to (E)-β-Nitrostyrene Catalysed by N-Toluensulfonyl-l-proline Amide in Ionic Liquids

    N-Toluensulfonyl-l-prolin amide was tested as catalyst in the enantioselective Michael addition of carbonyl compounds to (E)-β-nitrostyrene in nine ionic liquids under different reaction conditio...

    Mária Mečiarová, Katarína Hubinská… in Monatshefte für Chemie - Chemical Monthly (2007)

  8. No Access

    Article

    Activation and thermostabilization effects of cyclic 2,3-diphosphoglycerate on enzymes from the hyperthermophilic Methanopyrus kandleri

    Enzymes involved in methane formation from carbon dioxide and dihydrogen in Methanopyrus kandleri require high concentrations (> 1 M) of lyotropic salts such as K2HPO4/KH2PO4 or (NH4)2SO4 for activity and for the...

    Seigo Shima, David A. Hérault, Albrecht Berkessel, R. K. Thauer in Archives of Microbiology (1998)