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Article
Open AccessCurcumin-based-fluorescent probes targeting ALDH1A3 as a promising tool for glioblastoma precision surgery and early diagnosis
Glioblastoma (GBM) is the most aggressive primary brain tumour for which both effective treatments and efficient tools for an early-stage diagnosis are lacking. Herein, we present curcumin-based fluorescent pr...
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Article
Open AccessBetulinic Acid Hydroxamate is Neuroprotective and Induces Protein Phosphatase 2A-Dependent HIF-1α Stabilization and Post-transcriptional Dephosphorylation of Prolyl Hydrolase 2
Huntington’s disease (HD) is a neurodegenerative disorder characterized by unwanted choreatic movements, behavioral and psychiatric disturbances, and dementia. The activation of the hypoxic response pathway th...
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Article
Betulinic acid hydroxamate prevents colonic inflammation and fibrosis in murine models of inflammatory bowel disease
Intestinal fibrosis is a common complication of inflammatory bowel disease (IBD) and is defined as an excessive accumulation of scar tissue in the intestinal wall. Intestinal fibrosis occurs in both forms of I...
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Article
Thiol-trap** natural products under the lens of the cysteamine assay: friends, foes, or simply alternatively reversible ligands?
The literature on thia-Michael acceptors is vast and can be cherry-picked to show either that these compounds pollute chemical libraries displaying unselective binding and propensity to toxicity, or, alternati...
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Article
Umbellulone modulates TRP channels
Inhalation of umbellulone (UMB), the offensive principle of the so-called “headache tree” (California bay laurel, Umbellularia californica Nutt.), causes a painful cold sensation. We therefore studied the action ...
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Article
Open AccessHot Cuisine as a Source of Anti-Inflammatory Drugs
The shift in nutritional sciences from survival and safety to the promotion of well-being has led to systematic investigations on the biological activity of natural products of dietary origin, questioning the ...
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Article
Non-pungent capsaicinoids from sweet pepper
Background: Capsiate, the non-pungent ester isoster of capsaicin, and its dihydroderivative are the major capsaicinoids of sweet peppers. The remarkable difference between the sensory properties of capsaicin vs ...
