![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Chapter
Potential BNCT Agents
Boron-containing nucleosides are attractive agents for BNCT1 because they may be (1) taken up selectively into tumors due to the high mitotic rate of tumor cells vs. normal cells, (2) intracellularly converted to...
-
Chapter
Evaluation of Carboranyl 2′-Deoxyuridine Derivatives as Substrates for Human Thymidine Kinases 1 and 2
Cellular nucleoside kinases play a pivotal role in the use of nucleosides for cancer and antiviral therapy.1 For BNCT, the cytosolic thymidine kinase (TK1) may be a particularly important target enzyme. TK1 activ...
-
Chapter
Strategies to Improve the Efficacy of Neutron Capture Therapy of Brain Tumors by Optimizing Delivery of Boron Compounds
As recently reviewed by us,1,2 considerable effort has been directed towards the design and synthesis of low and high molecular weight boron delivery agents to target brain tumors for neutron capture therapy. Unt...
-
Chapter
Biological Evaluation of Boronated Polyamines as Potential Agents for BNCT
The use of BNCT as a cancer treatment modality has been well documented.1,2 The boron-containing delivery agent should be non-toxic, selectively target tumor cells and ideally localize within the nucleus. Various...
-
Article
Boron neutron capture therapy of brain tumors – current status and future prospects
-
Article
The rationale and requirements for the development of boron neutron capture therapy of brain tumors
The dismal clinical results in the treatment ofglioblastoma multiforme despite aggressive surgery, conventional radiotherapy, andchemotherapy, either alone or in combination has ledto the development of altern...
-
Chapter
Epidermal Growth Factor (EGF) as a Potential Targeting Agent for Delivery of Boron to Malignant Gliomas
The majority of high grade gliomas express an amplified epidermal growth factor receptor (EGFR) gene, and this often is associated with an increase in cell surface receptor expression1,2.
-
Chapter
New Unnatural Boron-Containing Amino Acids and Peptides as Potential Delivery Agents for Neutron Capture Therapy
Since Boron Neutron Capture Therapy is to be used in the treatment of primary and metastatic brain tumors, it is essential that the boron compounds be capable of crossing the blood-brain barrier (BBB) prior to...
-
Chapter
Sodium Borocaptate and Boronopheynlalanine Alone or in Combination as Capture Agents for BNCT of the F98 Rat Glioma
Sodium borocaptate (Na2B12H11SH, designated as “BSH”) has been used clinically in Japan for over 25 years by Hatanaka et al. as a capture agent for boron neutron capture therapy (BNCT) of brain tumors.1 Independe...
-
Chapter
Synthesis of 5-S-Alkylcarboranyl-2′-Deoxyuridines
Since glioma cells are more mitotically active than normal brain cells, they have an increased demand for nucleic acids to synthesize DNA. Several boronated nucleosides have been synthesized to take advantage ...
-
Chapter
Potential Use of Bispecific Antibodies (BSABS) for Targeting Gliomas and Melanomas
A major requirement for the success of BNCT is the selective delivery of boron to individual tumor cells 1,2. Monoclonal antibodies (MoAbs) have been used as selective delivery agents for drugs, toxins and radion...
-
Chapter
Synthesis and Biochemical Evaluation of 5-Tethered Boron-Containing Pyrimidine Nucleosides for BNCT
In order for BNCT to be successful, a major need is the development of boron compounds, which penetrate the blood-brain barrier (BBB), target tumor cells selectively, and maintain a relatively high concentrati...
-
Article
Boron neutron capture therapy of primary and metastatic brain tumors
Boron neutron capture therapy (BNCT) is based on the nuclear reaction that occurs when a stable isotope, boron-10, is irradiated with low energy (0.025 eV) thermal neutrons (n th) to yield alpha (4He) particles a...
-
Book
-
Chapter
Compound Development and Analytical Studies
For Neutron Capture Therapy (NCT) to become a useful clinical modality for treating solid tumors for which current therapies are of marginal utility, it is of crucial importance that effective compounds be des...
-
Chapter
Synthesis of Carborane-Containing Nucleosides, Nucleotides, and Carbohydrates for Bnct
The radiobiological effectiveness of the neutron capture reaction is 2-5 times greater when it occurs in the cell nucleus rather than in the cytoplasm.1,2 Boronated nucleic acid precursors and components may be s...
-
Chapter
Synthesis and Evaluation of Carborane-Containing Amino Acids for Boron Neutron Capture Therapy
Malignant melanoma, a neoplasm derived from neuroectodermal cells, is usually cutaneous in origin but can arise in a wide variety of extracutaneous sites including the oral, rectal and vaginal mucosa and the e...
-
Chapter
Subcellular Localization Study of Boronated Uridine and Glucose Derivatives in Cell Cultures Using Ion Microscopy
The success of boron neutron capture therapy depends on the uptake and retention of boron by tumor cells. The precise intracellular localization and concentration of boron must be known to be able to estimate ...
-
Chapter
Cellular Uptake, Subcellular Distribution and In Vitro Toxicity of Carboranyl Uridines
It has been known that the biological effects of BNCT can be maximized if 10B can be delivered to the nuclei of tumor cells so that there is a greater probability that alpha particles and 7Li nuclei will discharg...
-
Chapter
In Vivo Distribution of Boronated Monoclonal Antibodies and Starburst Dendrimers
Monoclonal antibodies (MoAbs) are theoretically among the most specific of all tumor targeting agents. In the span of ten years a voluminous literature has developed on their potential use for the diagnosis an...