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  1. No Access

    Article

    Role of phosphatidylinositol 3-kinase (PI3K) and Akt1 kinase in porcine reproductive and respiratory syndrome virus (PRRSV) replication

    We have previously reported that inhibition of phosphatidylinositol 3-kinase (PI3K) reduces porcine reproductive and respiratory syndrome (PRRSV) replication. Here, we further investigate the mechanism by whic...

    **uqing Wang, Hanmo Zhang, Alex M. Abel, Alan J. Young, Liji **e… in Archives of Virology (2014)

  2. Article

    Open Access

    The effect of bovine viral diarrhea virus (BVDV) strains on bovine monocyte-derived dendritic cells (Mo-DC) phenotype and capacity to produce BVDV

    Dendritic cells (DC) are important antigen presentation cells that monitor, process, and present antigen to T cells. Viruses that infect DC can have a devastating impact on the immune system. In this study, th...

    Mrigendra KS Rajput, Mahmoud F Darweesh, Kaci Park, Lyle J Braun… in Virology Journal (2014)

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  3. Article

    Open Access

    Classical scrapie prions in ovine blood are associated with B lymphocytes and platelet-rich plasma

    Classical scrapie is a naturally occurring transmissible spongiform encephalopathy of sheep and goats characterized by cellular accumulation of abnormal isoforms of prion protein (PrPSc) in the central nervous sy...

    Rohana P Dassanayake, David A Schneider, Thomas C Truscott… in BMC Veterinary Research (2011)

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  4. No Access

    Article

    Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues

    Lymphocytes travel throughout the body to carry out immune surveillance and participate in inflammatory reactions. Their path takes them from blood through tissues into lymph and back to blood. Molecules that ...

    Gudrun F Debes, Carrie N Arnold, Alan J Young, Stefan Krautwald… in Nature Immunology (2005)