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Article
Open AccessData and Tools Integration in the Canadian Open Neuroscience Platform
We present the Canadian Open Neuroscience Platform (CONP) portal to answer the research community’s need for flexible data sharing resources and provide advanced tools for search and processing infrastructure ...
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Article
Open AccessA critical role of brain network architecture in a continuum model of autism spectrum disorders spanning from healthy individuals with genetic liability to individuals with ASD
Studies have shown cortical alterations in individuals with autism spectrum disorders (ASD) as well as in individuals with high polygenic risk for ASD. An important addition to the study of altered cortical an...
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Article
Open AccessReproducibility of cerebellar involvement as quantified by consensus structural MRI biomarkers in advanced essential tremor
Essential tremor (ET) is the most prevalent movement disorder with poorly understood etiology. Some neuroimaging studies report cerebellar involvement whereas others do not. This discrepancy may stem from unde...
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Article
Open AccessConsent Codes: Maintaining Consent in an Ever-expanding Open Science Ecosystem
We previously proposed a structure for recording consent-based data use ‘categories’ and ‘requirements’ – Consent Codes – with a view to supporting maximum use and integration of genomic research datasets, and...
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Article
Open AccessMultiscale neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology
It is increasingly recognized that multiple psychiatric conditions are underpinned by shared neural pathways, affecting similar brain systems. Here, we carried out a multiscale neural contextualization of shar...
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Article
Open AccessThe C-BIG Repository: an Institution-Level Open Science Platform
In January 2016, the Montreal Neurological Institute-Hospital (The Neuro) declared itself an Open Science organization. This vision extends beyond efforts by individual scientists seeking to release individual...
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Article
Open AccessAuthor Correction: Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease
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Open AccessThe LORIS MyeliNeuroGene rare disease database for natural history studies and clinical trial readiness
Rare diseases are estimated to affect 150–350 million people worldwide. With advances in next generation sequencing, the number of known disease-causing genes has increased significantly, opening the door for ...
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Article
Open AccessImplication of metabolic and dopamine transporter PET in dementia with Lewy bodies
To evaluate the implication of 18F-fluorodeoxyglucose (FDG)- and dopamine transporter (DAT)-positron emission tomography (PET) in the diagnosis and clinical symptoms of dementia with Lewy bodies (DLB), 55 DLB pat...
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Article
The ENIGMA Toolbox: multiscale neural contextualization of multisite neuroimaging datasets
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Article
Four distinct trajectories of tau deposition identified in Alzheimer’s disease
Alzheimer’s disease (AD) is characterized by the spread of tau pathology throughout the cerebral cortex. This spreading pattern was thought to be fairly consistent across individuals, although recent work has ...
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Article
Open AccessThe Cuban Human Brain Map** Project, a young and middle age population-based EEG, MRI, and cognition dataset
The Cuban Human Brain Map** Project (CHBMP) repository is an open multimodal neuroimaging and cognitive dataset from 282 young and middle age healthy participants (31.9 ± 9.3 years, age range 18–68 years). T...
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Networks-Mediated Spreading of Pathology in Neurodegenerative Diseases
In addition to their basic anatomical and functional roles, brain connections are a relevant conduit for the spreading of pathological factors that cause disease. In this chapter, we focus on connectivity-medi...
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Article
Open AccessMutations associated with neuropsychiatric conditions delineate functional brain connectivity dimensions contributing to autism and schizophrenia
16p11.2 and 22q11.2 Copy Number Variants (CNVs) confer high risk for Autism Spectrum Disorder (ASD), schizophrenia (SZ), and Attention-Deficit-Hyperactivity-Disorder (ADHD), but their impact on functional conn...
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Article
Open AccessSpread of pathological tau proteins through communicating neurons in human Alzheimer’s disease
Tau is a hallmark pathology of Alzheimer’s disease, and animal models have suggested that tau spreads from cell to cell through neuronal connections, facilitated by β-amyloid (Aβ). We test this hypothesis in huma...
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Article
Open AccessEEG-IP: an international infant EEG data integration platform for the study of risk and resilience in autism and related conditions
Establishing reliable predictive and diganostic biomarkers of autism would enhance early identification and facilitate targeted intervention during periods of greatest plasticity in early brain development. Hi...
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Article
Open AccessA molecular gradient along the longitudinal axis of the human hippocampus informs large-scale behavioral systems
The functional organization of the hippocampus is distributed as a gradient along its longitudinal axis that explains its differential interaction with diverse brain systems. We show that the location of human...
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Article
A five-year longitudinal study reveals progressive cortical thinning in narcolepsy and faster cortical thinning in relation to early-onset
Narcolepsy with cataplexy is characterized by excessive daytime sleepiness, cataplexy, and other REM sleep phenomena. Previous MRI studies were cross-sectional in design and could not adequately address if dis...
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Article
White matter microstructure is associated with hyperactive/inattentive symptomatology and polygenic risk for attention-deficit/hyperactivity disorder in a population-based sample of adolescents
Few studies have investigated the link between putative biomarkers of attention-deficit/hyperactivity disorder (ADHD) symptomatology and genetic risk for ADHD. To address this, we investigate the degree to whi...
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Article
Neuroanatomical differences in obesity: meta-analytic findings and their validation in an independent dataset
Obesity has been linked with subtle differences in brain structure. These differences tend to be especially relevant in prefrontal cortex regions, areas which play an important role in executive control. Howev...
