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Article
Open AccessPrestressed cells are prone to cytoskeleton failures under localized shear strain: an experimental demonstration on muscle precursor cells
We report on a wavelet based space-scale decomposition method for analyzing the response of living muscle precursor cells (C2C12 myoblasts and myotubes) upon sharp indentation with an AFM cantilever and quanti...
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Article
Open AccessMulti-scale structural community organisation of the human genome
Structural interaction frequency matrices between all genome loci are now experimentally achievable thanks to high-throughput chromosome conformation capture technologies. This ensues a new methodological chal...
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Article
Open AccessEvidence of selection for an accessible nucleosomal array in human
Recently, a physical model of nucleosome formation based on sequence-dependent bending properties of the DNA double-helix has been used to reveal some enrichment of nucleosome-inhibiting energy barriers (NIEBs...
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Article
Open AccessAnalysis of fine-scale mammalian evolutionary breakpoints provides new insight into their relation to genome organisation
The Intergenic Breakage Model, which is the current model of structural genome evolution, considers that evolutionary rearrangement breakages happen with a uniform propensity along the genome but are selected ...