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Article
An Effective Integrated Framework for Fetal QRS Complex Detection Based on Abdominal ECG Signal
Non-invasive fetal electrocardiography (fECG) has a promising application prospect in offering crucial information for assessing early diagnosis and intervention of fetal distress and morbidity during pregnanc...
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Article
An Integrated Framework for Assessing the Quality of Non-invasive Fetal Electrocardiography Signals
Non-invasive fetal electrocardiography (fECG) offers crucial information for assessing early diagnosis of fetal distress and morbidity. However, the non-invasive fECG signals probably contain various non-stati...
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Article
Open AccessAssociation of air pollution exposure and increased coronary artery disease risk: the modifying effect of genetic susceptibility
Both genetic factors and air pollution are risk factors for coronary artery disease (CAD), but their combined effects on CAD are uncertain. The study aimed to comprehensively investigate their separate, combin...
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Article
Cathepsin B S-nitrosylation promotes ADAR1-mediated editing of its own mRNA transcript via an ADD1/MATR3 regulatory axis
Genetic information is generally transferred from RNA to protein according to the classic “Central Dogma”. Here, we made a striking discovery that post-translational modification of a protein specifically regu...
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Article
Open AccessDietary diosgenin transcriptionally down-regulated intestinal NPC1L1 expression to prevent cholesterol gallstone formation in mice
Cholesterol gallstone disease is a common disease. Reducing cholesterol burden is important to prevent/treat gallstone. In this study, we investigated the application of diosgenin (DG) to prevent the formation...
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Chapter and Conference Paper
Analysis of Path Optimization Problem Based on Reinforcement Learning
Path planning is to enable the target object to find a safe collision-free path from the beginning to the end within the specified area at the minimum time or distance cost. This paper elaborates the path plan...
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Article
Open AccessInteractions among maternal smoking, breastfeeding, and offspring genetic factors on the risk of adult-onset hypertension
Previous studies have reported that maternal smoking during pregnancy and breastfeeding may affect the occurrence of hypertension, but whether early life factors modify the impact of the offspring’s genetic ri...
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Article
Understanding gilteritinib resistance to FLT3-F691L mutation through an integrated computational strategy
FMS-like tyrosine kinase 3 (FLT3) serves as an important drug target for acute myeloid leukemia (AML), and gene mutations of FLT3 have been closely associated with AML patients with an incidence rate of ~ 30%....
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Article
Association between urinary cadmium concentrations and liver function in adolescents
Evidence from previous studies has shown that exposure to cadmium (Cd) is associated with cardiovascular disease, kidney disease, and osteoporosis, but the effects of Cd on liver toxicity in adolescents are un...
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Article
Total cholesterol: a potential mediator of the association between exposure to acrylamide and hypertension risk in adolescent females
Acrylamide (AA) exposure is associated with a range of adverse health effects. However, whether AA exposure is related to hypertension in adolescents remains unclear. The associations of blood hemoglobin bioma...
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Article
Open AccessGut microbiota promotes cholesterol gallstone formation by modulating bile acid composition and biliary cholesterol secretion
Cholesterol gallstone disease is a worldwide common disease. Cholesterol supersaturation in gallbladder bile is the prerequisite for its pathogenesis, while the mechanism is not completely understood. In this ...
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Article
Open AccessAn Axin2 mutation and perinatal risk factors contribute to sagittal craniosynostosis: evidence from a Chinese female monochorionic diamniotic twin family
Craniosynostosis, defined as premature fusion of one or more cranial sutures, affects approximately 1 in every 2000–2500 live births. Sagittal craniosynostosis (CS), the most prevalent form of isolated cranios...
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Article
Quality of life after dual kidney transplant: a systematic review
This article presents a review of quality of life among (QoL) dual kidney transplant (DKT) patients.
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Protocol
Quantification of Mitochondrial Genome Transcription in Male Reproductive Cells by Real-Time PCR
Mitochondria are organelles that play a key role in the regulation of cell energy metabolism, biosynthesis, and cell death. Mitochondria are also involved in important physiological processes, such as the thre...
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Article
RhoG-ELMO1-RAC1 is involved in phagocytosis suppressed by mono-butyl phthalate in TM4 cells
Di-n-butyl phthalate (DBP) is one of the most dominant phthalate esters and is ubiquitous in the environment. Male reproductive toxicity of DBP and its active metabolite mono-butyl phthalate (MBP) has been demons...
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Article
Open AccessBerberine ameliorates blockade of autophagic flux in the liver by regulating cholesterol metabolism and inhibiting COX2-prostaglandin synthesis
Excessive cholesterol contributes to the development of cardiovascular diseases. Berberine (BBR) has been reported to regulate cholesterol homeostasis. Here, we found that BBR could ameliorate the hepatic auto...
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Article
Nuclear norm regularized convolutional Max Pos@Top machine
In this paper, we propose a novel classification model for the multiple instance data, which aims to maximize the number of positive instances ranked before the top-ranked negative instances. This method belo...
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Article
Open AccessInvolvement of Insulin Signaling Disturbances in Bisphenol A-Induced Alzheimer’s Disease-like Neurotoxicity
Bisphenol A (BPA), a member of the environmental endocrine disruptors (EDCs), has recently received increased attention because of its effects on brain insulin resistance. Available data have indicated that br...
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Article
Measuring Object-Oriented Class Cohesion Based on Complex Networks
Class cohesion has an immediate impact on maintainability, modifiability and understandability of the software. Here, a new metric of cohesion based on complex networks (CBCN) for measuring connectivity of cla...
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Article
Open AccessIbrutinib, a Bruton’s tyrosine kinase inhibitor, exhibits antitumoral activity and induces autophagy in glioblastoma
Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults. Ibrutinib, a Bruton’s tyrosine kinase (BTK) inhibitor, is a novel anticancer drug used for treating several types of cancers....
